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Literature summary for 2.3.1.57 extracted from

  • Pietila, M.; Pirinen, E.; Keskitalo, S.; Juutinen, S.; Pasonen-Seppanen, S.; Keinanen, T.; Alhonen, L.; Janne, J.
    Disturbed keratinocyte differentiation in transgenic mice and organotypic keratinocyte cultures as a result of spermidine/spermine N-acetyltransferase overexpression (2005), J. Invest. Dermatol., 124, 596-601.
    View publication on PubMed
Search for more literature for 2.3.1.57

Cloned(Commentary)

Cloned (Comment) Organism
expression in a rat epidermal cell line, enzyme overexpression in transgenic mice Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information enzyme overexpression in transgenic mice leads to accumulation of purtrescine and permanent hair loss at the age of 3-weeks, because the hair follicles are exchanged for dermal cysts and epidermal utriculi due to reduced expression of terminal differentiation markers such as cytokeratins 1/10, and filaggrin, and persisting expression of basal cell cytokeratins 5/14 in the suprabasal layer, hair growth can be reactivated by reduction of putrescine content Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + spermidine Mus musculus
-
 CoA + N1-acetylspermidine
-
 ?
acetyl-CoA + spermine Mus musculus
-
 CoA + N1-acetylspermine
-
 ?
additional information Mus musculus the enzyme is rate-limiting in polyamine catabolism ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epidermis
-
 Mus musculus
-
keratinocyte
-
 Mus musculus
-
skin
-
 Mus musculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 polyamine content in different clones of a transfected rat epidermal cell line expressing the enzyme, overview Mus musculus
0.000003 0.00008 activity in different clones of a transfected rat epidermal cell line expressing the enzyme Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + spermidine
-
 Mus musculus CoA + N1-acetylspermidine
-
 ?
acetyl-CoA + spermine
-
 Mus musculus CoA + N1-acetylspermine
-
 ?
additional information the enzyme is rate-limiting in polyamine catabolism Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
spermidine/spermine N-acetyltransferase
-
 Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Mus musculus