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Literature summary for 2.3.1.6 extracted from
- Choline acetyltransferase and acetylcholinesterase activities are reduced in rat striatum and frontal cortex after pilocarpine-induced seizures (2010), Neurosci. Lett., 469, 81-83.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| bromoacetylcholine | a selective inhibitor of choline acetyltransferase | Rattus norvegicus |  |
| pilocarpine | the enzyme activity in striatum and frontal cortex is reduced after pilocarpine-induced seizures | Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + choline | Rattus norvegicus | - |
CoA + O-acetylcholine | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
male Wistar rats | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Rattus norvegicus | - |
| frontal cortex | - |
Rattus norvegicus | - |
| striatum | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + choline | - |
Rattus norvegicus | CoA + O-acetylcholine | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ChAT | - |
Rattus norvegicus |
| choline acetyltransferase | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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