Any feedback?
Literature summary for 2.3.1.7 extracted from
- Peroxisomal and mitochondrial carnitine acetyltransferases in alkane-grown yeast Candida tropicalis (1982), Eur. J. Biochem., 124, 205-210.
General Stability
| General Stability | Organism |
|---|---|
| inactivated under the conditions of freeze/thaw | Candida tropicalis |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 5,5'-dithio-bis(2-nitrobenzoic acid) | - |
Rattus norvegicus |  |
| 5,5'-dithio-bis(2-nitrobenzoic acid) | - |
Sus scrofa | |
| Ca2+ | - |
Candida tropicalis | |
| Mg2+ | - |
Candida tropicalis | |
| p-chloromercuribenzoic acid | - |
Candida tropicalis | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.036 | - |
acetyl-CoA | mitochondrial enzyme | Candida tropicalis | |
| 0.042 | - |
acetyl-CoA | peroxisomal enzyme | Candida tropicalis | |
| 0.1 | - |
propionyl-CoA | peroxisomal enzyme | Candida tropicalis | |
| 0.162 | - |
propionyl-CoA | mitochondrial enzyme | Candida tropicalis | |
| 0.257 | - |
CoASH | mitochondrial enzyme | Candida tropicalis | |
| 0.304 | - |
CoASH | peroxisomal enzyme | Candida tropicalis | |
| 0.417 | - |
acetylcarnitine | peroxisomal enzyme | Candida tropicalis | |
| 0.622 | - |
L-carnitine | mitochondrial enzyme, second substrate acetyl-CoA | Candida tropicalis | |
| 0.639 | - |
acetylcarnitine | mitochondrial enzyme | Candida tropicalis | |
| 0.655 | - |
L-carnitine | peroxisomal enzyme, second substrate propionyl-CoA | Candida tropicalis | |
| 0.719 | - |
L-carnitine | peroxisomal enzyme, second substrate acetyl-CoA | Candida tropicalis | |
| 0.774 | - |
L-carnitine | mitochondrial enzyme, second substrate propionyl-CoA | Candida tropicalis | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Rattus norvegicus | - |
- |
| microsome | - |
Candida tropicalis | - |
- |
| microsome | - |
Columba sp. | - |
- |
| mitochondrion | - |
Rattus norvegicus | 5739 | - |
| mitochondrion | - |
Candida tropicalis | 5739 | - |
| peroxisome | - |
Rattus norvegicus | 5777 | - |
| peroxisome | - |
Candida tropicalis | 5777 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + carnitine | Rattus norvegicus | - |
O-acetylcarnitine + CoASH | - |
r | |
| acetyl-CoA + carnitine | Sus scrofa | - |
O-acetylcarnitine + CoASH | - |
r | |
| acetyl-CoA + carnitine | Candida tropicalis | - |
O-acetylcarnitine + CoASH | - |
r | |
| acetyl-CoA + carnitine | Columba sp. | - |
O-acetylcarnitine + CoASH | - |
r | |
| acyl-CoA + carnitine | Rattus norvegicus | - |
acylcarnitine + CoASH | - |
r | |
| acyl-CoA + carnitine | Sus scrofa | - |
acylcarnitine + CoASH | - |
r | |
| acyl-CoA + carnitine | Candida tropicalis | - |
acylcarnitine + CoASH | - |
r | |
| acyl-CoA + carnitine | Columba sp. | - |
acylcarnitine + CoASH | - |
r | |
| acylcarnitine + CoASH | Rattus norvegicus | - |
acyl-CoA + carnitine | - |
r | |
| acylcarnitine + CoASH | Sus scrofa | - |
acyl-CoA + carnitine | - |
r | |
| acylcarnitine + CoASH | Candida tropicalis | - |
acyl-CoA + carnitine | - |
r | |
| acylcarnitine + CoASH | Columba sp. | - |
acyl-CoA + carnitine | - |
r | |
| O-acetylcarnitine + CoASH | Rattus norvegicus | - |
acetyl-CoA + carnitine | - |
r | |
| O-acetylcarnitine + CoASH | Sus scrofa | - |
acetyl-CoA + carnitine | - |
r | |
| O-acetylcarnitine + CoASH | Candida tropicalis | - |
acetyl-CoA + carnitine | - |
r | |
| O-acetylcarnitine + CoASH | Columba sp. | - |
acetyl-CoA + carnitine | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Candida tropicalis | - |
yeast | - |
| Candida tropicalis | - |
(Castellani) Berkhout strain pK233(ATCC 20336) | - |
| Columba sp. | - |
pigeon | - |
| Rattus norvegicus | - |
rat | - |
| Sus scrofa | - |
pig | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| mitochondrial and peroxisomal enzyme | Candida tropicalis |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| breast muscle | - |
Columba sp. | - |
| liver | - |
Rattus norvegicus | - |
| liver | - |
Columba sp. | - |
| muscle | - |
Rattus norvegicus | - |
| muscle | - |
Columba sp. | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 88.5 | - |
peroxisomal enzyme | Candida tropicalis |
| 113 | - |
- |
Candida tropicalis |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + carnitine | - |
Rattus norvegicus | O-acetylcarnitine + CoASH | - |
r | |
| acetyl-CoA + carnitine | - |
Sus scrofa | O-acetylcarnitine + CoASH | - |
r | |
| acetyl-CoA + carnitine | - |
Candida tropicalis | O-acetylcarnitine + CoASH | - |
r | |
| acetyl-CoA + carnitine | - |
Columba sp. | O-acetylcarnitine + CoASH | - |
r | |
| acetyl-CoA + L-(-)carnitine | - |
Rattus norvegicus | O-acetylcarnitine + CoASH | - |
r | |
| acetyl-CoA + L-(-)carnitine | - |
Sus scrofa | O-acetylcarnitine + CoASH | - |
r | |
| acetyl-CoA + L-(-)carnitine | - |
Candida tropicalis | O-acetylcarnitine + CoASH | - |
r | |
| acetyl-CoA + L-(-)carnitine | - |
Columba sp. | O-acetylcarnitine + CoASH | - |
r | |
| acyl-CoA + carnitine | - |
Rattus norvegicus | acylcarnitine + CoASH | - |
r | |
| acyl-CoA + carnitine | - |
Sus scrofa | acylcarnitine + CoASH | - |
r | |
| acyl-CoA + carnitine | - |
Candida tropicalis | acylcarnitine + CoASH | - |
r | |
| acyl-CoA + carnitine | - |
Columba sp. | acylcarnitine + CoASH | - |
r | |
| acylcarnitine + CoASH | - |
Rattus norvegicus | acyl-CoA + carnitine | - |
r | |
| acylcarnitine + CoASH | - |
Sus scrofa | acyl-CoA + carnitine | - |
r | |
| acylcarnitine + CoASH | - |
Candida tropicalis | acyl-CoA + carnitine | - |
r | |
| acylcarnitine + CoASH | - |
Columba sp. | acyl-CoA + carnitine | - |
r | |
| decanoyl-CoA + carnitine | - |
Rattus norvegicus | decanoylcarnitine + CoASH | - |
r | |
| decanoyl-CoA + carnitine | - |
Sus scrofa | decanoylcarnitine + CoASH | - |
r | |
| decanoyl-CoA + carnitine | - |
Columba sp. | decanoylcarnitine + CoASH | - |
r | |
| decanoylcarnitine + CoASH | - |
Rattus norvegicus | decanoyl-CoA + carnitine | - |
r | |
| decanoylcarnitine + CoASH | - |
Sus scrofa | decanoyl-CoA + carnitine | - |
r | |
| decanoylcarnitine + CoASH | - |
Columba sp. | decanoyl-CoA + carnitine | - |
r | |
| hexanoyl-CoA + carnitine | - |
Rattus norvegicus | hexanoylcarnitine + CoASH | - |
r | |
| hexanoyl-CoA + carnitine | - |
Sus scrofa | hexanoylcarnitine + CoASH | - |
r | |
| hexanoyl-CoA + carnitine | - |
Columba sp. | hexanoylcarnitine + CoASH | - |
r | |
| hexanoylcarnitine + CoASH | - |
Rattus norvegicus | hexanoyl-CoA + carnitine | - |
r | |
| hexanoylcarnitine + CoASH | - |
Sus scrofa | hexanoyl-CoA + carnitine | - |
r | |
| hexanoylcarnitine + CoASH | - |
Columba sp. | hexanoyl-CoA + carnitine | - |
r | |
| additional information | - |
Rattus norvegicus | ? | - |
? | |
| additional information | - |
Sus scrofa | ? | - |
? | |
| additional information | - |
Columba sp. | ? | - |
? | |
| additional information | pentanoyl-CoA, hexanoyl-CoA, decanoyl-CoA and palmitoyl-CoA are no substrates | Candida tropicalis | ? | - |
? | |
| O-acetylcarnitine + CoASH | - |
Rattus norvegicus | acetyl-CoA + L-(-)carnitine | - |
r | |
| O-acetylcarnitine + CoASH | - |
Sus scrofa | acetyl-CoA + L-(-)carnitine | - |
r | |
| O-acetylcarnitine + CoASH | - |
Candida tropicalis | acetyl-CoA + L-(-)carnitine | - |
r | |
| O-acetylcarnitine + CoASH | - |
Columba sp. | acetyl-CoA + L-(-)carnitine | - |
r | |
| O-acetylcarnitine + CoASH | - |
Rattus norvegicus | acetyl-CoA + carnitine | - |
r | |
| O-acetylcarnitine + CoASH | - |
Sus scrofa | acetyl-CoA + carnitine | - |
r | |
| O-acetylcarnitine + CoASH | - |
Candida tropicalis | acetyl-CoA + carnitine | - |
r | |
| O-acetylcarnitine + CoASH | - |
Columba sp. | acetyl-CoA + carnitine | - |
r | |
| propionyl-CoA + L-(-)carnitine | - |
Rattus norvegicus | propionylcarnitine + CoASH | - |
r | |
| propionyl-CoA + L-(-)carnitine | - |
Candida tropicalis | propionylcarnitine + CoASH | - |
r | |
| propionylcarnitine + CoASH | - |
Rattus norvegicus | propionyl-CoA + L-(-)carnitine | - |
r | |
| propionylcarnitine + CoASH | - |
Candida tropicalis | propionyl-CoA + L-(-)carnitine | - |
r | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
- |
Rattus norvegicus |
| 8 | - |
- |
Candida tropicalis |
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