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Literature summary for 2.3.1.7 extracted from
- Crystal structure of carnitine acetyltransferase and implications for the catalytic mechanism and fatty acid transport (2003), Cell, 112, 113-122.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | dysregulation of the enzyme can lead to serious diseases in humans, inherited deficiency in CRAT activity can lead to neurological and heart problems, patients suffering from Alzheimer 's disease also have reduced CRAT activity, promising target for therapeutic development against several human diseases like diabetes | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Mus musculus |
- |
Homo sapiens |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| sitting drop vapor diffusion method, space group C2, cell dimensions for the free enzyme crystal a: 158.9 A, b: 89.6 A, c: 119.4 A, beta: 127.5° | Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + carnitine | Mus musculus | - |
O-acetylcarnitine + CoASH | - |
r |  |
| acetyl-CoA + carnitine | Homo sapiens | - |
O-acetylcarnitine + CoASH | - |
r | |
| acyl-CoA + carnitine | Mus musculus | - |
acylcarnitine + CoASH | - |
r | |
| acyl-CoA + carnitine | Homo sapiens | - |
acylcarnitine + CoASH | - |
r | |
| acylcarnitine + CoASH | Mus musculus | - |
acyl-CoA + carnitine | - |
r | |
| acylcarnitine + CoASH | Homo sapiens | - |
acyl-CoA + carnitine | - |
r | |
| O-acetylcarnitine + CoASH | Mus musculus | - |
acetyl-CoA + carnitine | - |
r | |
| O-acetylcarnitine + CoASH | Homo sapiens | - |
acetyl-CoA + carnitine | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
human | - |
| Mus musculus | - |
mouse | - |
| Mus musculus | P47934 | mouse, Protein Data Bank accession number | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + carnitine | - |
Mus musculus | O-acetylcarnitine + CoASH | - |
r | |
| acetyl-CoA + carnitine | - |
Homo sapiens | O-acetylcarnitine + CoASH | - |
r | |
| acetyl-CoA + L-(-)carnitine | - |
Mus musculus | O-acetylcarnitine + CoASH | - |
r | |
| acetyl-CoA + L-(-)carnitine | - |
Homo sapiens | O-acetylcarnitine + CoASH | - |
r | |
| acyl-CoA + carnitine | - |
Mus musculus | acylcarnitine + CoASH | - |
r | |
| acyl-CoA + carnitine | - |
Homo sapiens | acylcarnitine + CoASH | - |
r | |
| acylcarnitine + CoASH | - |
Mus musculus | acyl-CoA + carnitine | - |
r | |
| acylcarnitine + CoASH | - |
Homo sapiens | acyl-CoA + carnitine | - |
r | |
| O-acetylcarnitine + CoASH | - |
Mus musculus | acetyl-CoA + L-(-)carnitine | - |
r | |
| O-acetylcarnitine + CoASH | - |
Homo sapiens | acetyl-CoA + L-(-)carnitine | - |
r | |
| O-acetylcarnitine + CoASH | - |
Mus musculus | acetyl-CoA + carnitine | - |
r | |
| O-acetylcarnitine + CoASH | - |
Homo sapiens | acetyl-CoA + carnitine | - |
r | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | - |
Mus musculus |
| monomer | - |
Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CAT | - |
Mus musculus |
| CAT | - |
Homo sapiens |
| CRAT | - |
Mus musculus |
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Release 2023.1 (January 2023)
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