Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.3.1.7 extracted from

  • Strijbis, K.; van Roermund, C.W.; van den Burg, J.; van den Berg, M.; Hardy, G.P.; Wanders, R.J.; Distel, B.
    Contributions of carnitine acetyltransferases to intracellular acetyl unit transport in Candida albicans (2010), J. Biol. Chem., 285, 24335-24346.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.7

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol isoforms Yat1 and Yat2 Candida albicans 5829
-
mitochondrion isoform Cat2 Candida albicans 5739
-
peroxisome isoform Cat2 Candida albicans 5777
-

Organism

Organism UniProt Comment Textmining
Candida albicans
-
-
-

Synonyms

Synonyms Comment Organism
CAT2
-
 Candida albicans
Yat1
-
 Candida albicans

General Information

General Information Comment Organism
physiological function carnitine acetyltransferase Yat1 is cytosolic and contributes to acetyl-CoA transport from the cytosol during growth on ethanol or acetate, but its activity is not required for growth on oleate Candida albicans
physiological function mitochondrial carnitine acetyltransferase Cat2 is required for the intramitochondrial conversion of acetylcarnitine to acetyl-CoA, which is essential for a functional tricarboxylic acid cycle during growth on oleate, acetate, ethanol, and citrate. Peroxisomal Cat2 is essential neither for export of acetyl units during growth on oleate nor for the import of acetyl units during growth on acetate or ethanol. Oxidation of fatty acids still takes place in the absence of peroxisomal Cat2, but biomass formation is absent, and the strain displays a growth delay on acetate and ethanol that can be partially rescued by the addition of carnitine Candida albicans