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Literature summary for 2.3.1.78 extracted from

  • Bame, K.J.; Rome, L.H.
    Acetyl-coenzyme A:alpha-glucosaminide N-acetyltransferase. Evidence for an active site histidine residue (1986), J. Biol. Chem., 261, 10127-10132.
    View publication on PubMed
Search for more literature for 2.3.1.78

Inhibitors

Inhibitors Comment Organism Structure
diethyl dicarbonate reversible by incubation with hydroxylamine, binds a histidine residue at the active site Rattus norvegicus
additional information iodoacetamide and N-ethylmaleimide are not inhibitory Rattus norvegicus
N-bromosuccinimide binds a histidine residue at the active site Rattus norvegicus
p-chloromercuribenzoate binding site is not the active site Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome enzyme is acetylated at the cytoplasmic side of the lysosome and the acetyl group is then transferred to the inside where it is used to acetylate heparan sulfate Rattus norvegicus 5764
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + heparan sulfate alpha-D-glucosaminide Rattus norvegicus
-
 CoA + heparan sulfate N-acetyl-alpha-D-glucosaminide
-
 ?
additional information Rattus norvegicus enzyme is acetylated at the cytoplasmic side of the lysosome and the acetyl group is then transferred to the inside where it is used to acetylate heparan sulfate ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
acetyl-CoA + heparan sulfate alpha-D-glucosaminide = CoA + heparan sulfate N-acetyl-alpha-D-glucosaminide transmembranal reaction mechanism Rattus norvegicus
a

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + heparan sulfate alpha-D-glucosaminide
-
 Rattus norvegicus CoA + heparan sulfate N-acetyl-alpha-D-glucosaminide
-
 ?
acetyl-CoA + heparan sulfate alpha-D-glucosaminide brings about the acetylation of glucosamine groups of heparan sulfate and heparin from which the sulfate has been removed Rattus norvegicus CoA + heparan sulfate N-acetyl-alpha-D-glucosaminide
-
 ?
additional information enzyme is acetylated at the cytoplasmic side of the lysosome and the acetyl group is then transferred to the inside where it is used to acetylate heparan sulfate Rattus norvegicus ?
-
 ?