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Literature summary for 2.3.1.78 extracted from

  • Meikle, P.J.; Whittle, A.M.; Hopwood, J.J.
    Human acetyl-coenzyme A:alpha-glucosaminide N-acetyltransferase. Kinetic characterization and mechanistic interpretation (1995), Biochem. J., 308, 327-333.
No PubMed abstract available

Inhibitors

Inhibitors Comment Organism Structure
coenzyme A noncompetitive Homo sapiens
desulfo-CoA competitive against acetyl-CoA Homo sapiens
N-acetyl-beta-D-glucosamine competitive against glucosamine; noncompetitive against acetyl-CoA Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0025
-
acetyl-CoA pH 7.0 Homo sapiens
0.003
-
beta-D-glucosamine pH 7.0 Homo sapiens
0.054
-
acetyl-CoA pH 5.0 Homo sapiens
0.37
-
beta-D-glucosamine pH 5.0 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome integral membrane protein Homo sapiens 5764
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + heparan sulfate alpha-D-glucosaminide Homo sapiens
-
CoA + heparan sulfate N-acetyl-alpha-D-glucosaminide
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
placenta
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.000673
-
lysosomal fraction Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + beta-D-glucosamine
-
Homo sapiens CoA + N-acetyl-beta-D-glucosamine
-
?
acetyl-CoA + heparan sulfate alpha-D-glucosaminide
-
Homo sapiens CoA + heparan sulfate N-acetyl-alpha-D-glucosaminide
-
?
acetyl-CoA + heparin alpha-D-glucosaminide also acetylates di- and tetrasaccharide fragments of heparin Homo sapiens CoA + heparin N-acetyl-D-glucosamine
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
additional information
-
-
Homo sapiens
6.5
-
tetrasaccharide substrate Homo sapiens
6.5 8 mono-and disaccharide substrates Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.032
-
coenzyme A versus acetyl-CoA Homo sapiens
0.082
-
coenzyme A versus beta-D-glucosamine Homo sapiens
0.21
-
desulfo-CoA versus beta-D-glucosamine Homo sapiens
0.22
-
desulfo-CoA versus acetyl-CoA Homo sapiens
3.8
-
N-acetyl-beta-D-glucosamine versus acetyl-CoA Homo sapiens
5.6
-
N-acetyl-beta-D-glucosamine versus glucosamine Homo sapiens