Application | Comment | Organism |
---|---|---|
medicine | a C-14T mutation in eis confers kanamycin resistance in Mycobacterium tuberculosis | Mycobacterium tuberculosis |
Cloned (Comment) | Organism |
---|---|
into the vector pET19b | Mycobacterium tuberculosis |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.112 | - |
amikacin | - |
Mycobacterium tuberculosis | |
0.154 | - |
kanamycin | - |
Mycobacterium tuberculosis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + aminoglycoside | Mycobacterium tuberculosis | - |
CoA + 6'-N-acetylaminoglycoside | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | - |
- |
- |
Purification (Comment) | Organism |
---|---|
on a His-Bind NiNTA column | Mycobacterium tuberculosis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + amikacin | aminoglycoside acetyltransferase eis acetylates and inactivates amikacin | Mycobacterium tuberculosis | CoA + 6'-N-acetylamikacin | - |
? | |
acetyl-CoA + aminoglycoside | - |
Mycobacterium tuberculosis | CoA + 6'-N-acetylaminoglycoside | - |
? | |
acetyl-CoA + kanamycin | aminoglycoside acetyltransferase eis acetylates and inactivates kanamycin | Mycobacterium tuberculosis | CoA + 6'-N-acetylkanamycin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
aminoglycoside acetyltransferase eis | - |
Mycobacterium tuberculosis |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
22 | - |
activity assay at room temperature | Mycobacterium tuberculosis |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
activity assay | Mycobacterium tuberculosis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
acetyl-CoA | - |
Mycobacterium tuberculosis |
Organism | Comment | Expression |
---|---|---|
Mycobacterium tuberculosis | C-14T mutation in eis increases expression of aminoglycoside acetyltransferase eis | up |