Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.3.1.87 extracted from

  • Isorna, E.; El Mrabet, A.; Confente, F.; Falcon, J.; Munoz-Cueto, J.A.
    Cloning and expression of arylalkylamine N-acetyltranferase-2 during early development and metamorphosis in the sole Solea senegalensis (2009), Gen. Comp. Endocrinol., 161, 97-102.
    View publication on PubMed
Search for more literature for 2.3.1.87

Cloned(Commentary)

Cloned (Comment) Organism
gene AANAT2, DNA and amino acid sequence determination and analysis, developmental expression analysis by quantitative real time PCR analysis, phylogenetic analysis, overview Solea senegalensis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + serotonin Solea senegalensis first step in melatonin biosynthesis CoA + N-acetylserotonin
-
 ?

Organism

Organism UniProt Comment Textmining
Solea senegalensis
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
larva isozyme AANAT2 developmental expression pattern, overview Solea senegalensis
-
pineal gland pineal gland-specific isozyme AANAT2 is specifically expressed in pineal opsin-immunoreactive photoreceptor cells, developmental expression pattern, s significant 60fold reduction in Aanat2 expression occurs just before metamorphosis, overview Solea senegalensis
-
retina retina-specific isozyme AANAT1 Solea senegalensis
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + serotonin
-
 Solea senegalensis CoA + N-acetylserotonin
-
 ?
acetyl-CoA + serotonin first step in melatonin biosynthesis Solea senegalensis CoA + N-acetylserotonin
-
 ?

Synonyms

Synonyms Comment Organism
AANAT
-
 Solea senegalensis
arylalkylamine N-acetyltransferase
-
 Solea senegalensis

General Information

General Information Comment Organism
metabolism the enzyme catalyzes the first step in melatonin biosynthesis, melatonin biosynthesis follows a 24 h day and night rhythm, which is different in fasted, fed, and refed fish, overview Solea senegalensis
physiological function Aanat2 is the main enzyme responsible of the plasma nocturnal melatonin increase in the fish Solea senegalensis