Cloned (Comment) | Organism |
---|---|
phylogenetic tree and analysis | Aedes aegypti |
Crystallization (Comment) | Organism |
---|---|
hanging-drop vapor diffusion method, mixing of 0.001 ml of both protein and reservoir solution, equilibration against 0.15 ml of reservoir solution containing 0.17 M ammonium acetate, 25.5% PEG 4000, and 17% glycerol, and 0.1 M sodium citrate, pH 5.6, X-ray diffraction structure determination and analysis, molecular replacement, modeling | Aedes aegypti |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + a 2-arylethylamine | Aedes aegypti | - |
CoA + an N-acetyl-2-arylethylamine | - |
? | |
acetyl-CoA + histamine | Aedes aegypti | - |
CoA + N-acetylhistamine | - |
? | |
additional information | Aedes aegypti | aaNAT2, a protein from the typical insect aaNAT cluster, uses histamine as a substrate as well as arylalkylamines | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Aedes aegypti | Q16KL9 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + a 2-arylethylamine | - |
Aedes aegypti | CoA + an N-acetyl-2-arylethylamine | - |
? | |
acetyl-CoA + histamine | - |
Aedes aegypti | CoA + N-acetylhistamine | - |
? | |
additional information | aaNAT2, a protein from the typical insect aaNAT cluster, uses histamine as a substrate as well as arylalkylamines | Aedes aegypti | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AANAT | - |
Aedes aegypti |
AANAT2 | - |
Aedes aegypti |
arylalkylamine N-acetyltransferase 2 | - |
Aedes aegypti |
serotonin N-acetyltransferase | - |
Aedes aegypti |
SNAT | - |
Aedes aegypti |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
acetyl-CoA | - |
Aedes aegypti |
General Information | Comment | Organism |
---|---|---|
evolution | evolution of insect arylalkylamine N-acetyltransferases, structural evidence from the yellow fever mosquito, Aedes aegypti, overview | Aedes aegypti |
additional information | three clusters of aaNAT-like sequences in insects: typical insect aaNAT, polyamine NAT-like aaNAT, and mosquito unique putative aaNAT, paaNAT. aaNAT2, a protein from the typical insect aaNAT cluster, uses histamine as a substrate as well as arylalkylamines | Aedes aegypti |
physiological function | aaNATs are involved in sclerotization and neurotransmitter inactivation in insects | Aedes aegypti |