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Literature summary for 2.3.1.87 extracted from

  • Han, Q.; Robinson, H.; Ding, H.; Christensen, B.M.; Li, J.
    Evolution of insect arylalkylamine N-acetyltransferases: structural evidence from the yellow fever mosquito, Aedes aegypti (2012), Proc. Natl. Acad. Sci. USA, 109, 11669-11674.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
phylogenetic tree and analysis Aedes aegypti

Crystallization (Commentary)

Crystallization (Comment) Organism
hanging-drop vapor diffusion method, mixing of 0.001 ml of both protein and reservoir solution, equilibration against 0.15 ml of reservoir solution containing 0.17 M ammonium acetate, 25.5% PEG 4000, and 17% glycerol, and 0.1 M sodium citrate, pH 5.6, X-ray diffraction structure determination and analysis, molecular replacement, modeling Aedes aegypti

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + a 2-arylethylamine Aedes aegypti
-
CoA + an N-acetyl-2-arylethylamine
-
?
acetyl-CoA + histamine Aedes aegypti
-
CoA + N-acetylhistamine
-
?
additional information Aedes aegypti aaNAT2, a protein from the typical insect aaNAT cluster, uses histamine as a substrate as well as arylalkylamines ?
-
?

Organism

Organism UniProt Comment Textmining
Aedes aegypti Q16KL9
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + a 2-arylethylamine
-
Aedes aegypti CoA + an N-acetyl-2-arylethylamine
-
?
acetyl-CoA + histamine
-
Aedes aegypti CoA + N-acetylhistamine
-
?
additional information aaNAT2, a protein from the typical insect aaNAT cluster, uses histamine as a substrate as well as arylalkylamines Aedes aegypti ?
-
?

Synonyms

Synonyms Comment Organism
AANAT
-
Aedes aegypti
AANAT2
-
Aedes aegypti
arylalkylamine N-acetyltransferase 2
-
Aedes aegypti
serotonin N-acetyltransferase
-
Aedes aegypti
SNAT
-
Aedes aegypti

Cofactor

Cofactor Comment Organism Structure
acetyl-CoA
-
Aedes aegypti

General Information

General Information Comment Organism
evolution evolution of insect arylalkylamine N-acetyltransferases, structural evidence from the yellow fever mosquito, Aedes aegypti, overview Aedes aegypti
additional information three clusters of aaNAT-like sequences in insects: typical insect aaNAT, polyamine NAT-like aaNAT, and mosquito unique putative aaNAT, paaNAT. aaNAT2, a protein from the typical insect aaNAT cluster, uses histamine as a substrate as well as arylalkylamines Aedes aegypti
physiological function aaNATs are involved in sclerotization and neurotransmitter inactivation in insects Aedes aegypti