Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Ce3+ | not reversible by Ca2+ | Homo sapiens | |
EDTA | - |
Homo sapiens | |
Gd3+ | not reversible by Ca2+ | Homo sapiens | |
La3+ | not reversible by Ca2+ | Homo sapiens | |
additional information | rapid inactivatin of factor XIIIa by trypsin and thrombin in the absence of metal ions | Homo sapiens | |
Tb3+ | noncompetitive inhibition of factor XIIIa, at high Ca2+-levels, not reversed by Ca2+ | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | requirement | Homo sapiens | |
Ca2+ | crucial during thrombin cleavage of factor XIII for the formation of factor XIIIa and factor XIIIa activation, Ln3+ can replace Ca2+ during trypsin activation of factor XIII but not in activation of factor XIIIa | Homo sapiens | |
La3+ | requirement, 0.01-0.1 mM | Homo sapiens | |
additional information | not activated by trivalenic lanthanide ions, 0.01-0.1 mM | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | activation of platelet factor XIII through thrombin cleavage at Arg37-Gly38 peptide bond leading to factor XIIIa | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.071 | - |
Tb3+ | - |
Homo sapiens |