Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.3.2.13 extracted from

  • Achyuthan, K.E.; Mary, A.; Greenberg, C.S.
    Tb(III)-ion-binding-induced conformational changes in platelet factor XIII (1989), Biochem. J., 257, 331-338.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
Ce3+ not reversible by Ca2+ Homo sapiens
EDTA
-
Homo sapiens
Gd3+ not reversible by Ca2+ Homo sapiens
La3+ not reversible by Ca2+ Homo sapiens
additional information rapid inactivatin of factor XIIIa by trypsin and thrombin in the absence of metal ions Homo sapiens
Tb3+ noncompetitive inhibition of factor XIIIa, at high Ca2+-levels, not reversed by Ca2+ Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ requirement Homo sapiens
Ca2+ crucial during thrombin cleavage of factor XIII for the formation of factor XIIIa and factor XIIIa activation, Ln3+ can replace Ca2+ during trypsin activation of factor XIII but not in activation of factor XIIIa Homo sapiens
La3+ requirement, 0.01-0.1 mM Homo sapiens
additional information not activated by trivalenic lanthanide ions, 0.01-0.1 mM Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification activation of platelet factor XIII through thrombin cleavage at Arg37-Gly38 peptide bond leading to factor XIIIa Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.071
-
Tb3+
-
Homo sapiens