Activating Compound | Comment | Organism | Structure |
---|---|---|---|
dithiothreitol | - |
Cavia porcellus | |
dithiothreitol | required for activity of lens transglutaminase | Oryctolagus cuniculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
GTP | - |
Cavia porcellus | |
GTP | - |
Homo sapiens | |
GTP | 0.05 mM, 50% inhibition of lens transglutaminase, 0.5 mM, complete inhibition in the presence of 0.5 mM Ca2+, increasing the Ca2+ concentration to 3 mM reverses inhibition | Oryctolagus cuniculus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | requirement | Cavia porcellus | |
Ca2+ | requirement | Homo sapiens | |
Ca2+ | requirement | Oryctolagus cuniculus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
78000 | - |
x * 78000, lens transglutaminase, SDS-PAGE | Oryctolagus cuniculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cavia porcellus | - |
- |
- |
Homo sapiens | - |
- |
- |
Oryctolagus cuniculus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
lens transglutaminase, DE-52, affinity chromatography on 42000 Da thermolytic fragment of human plasma fibronectin | Oryctolagus cuniculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
lens | - |
Oryctolagus cuniculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
monodansylcadaverine + N,N-dimethylcasein | - |
Oryctolagus cuniculus | ? | - |
? | |
protein-bound gamma-glutamine + alkylamine | - |
Cavia porcellus | protein N5-alkylglutamine + NH3 | - |
? | |
protein-bound gamma-glutamine + alkylamine | - |
Homo sapiens | protein N5-alkylglutamine + NH3 | - |
? | |
protein-bound gamma-glutamine + alkylamine | lens transglutaminase, crosslinking of beta-crystallin | Oryctolagus cuniculus | protein N5-alkylglutamine + NH3 | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | - |
Homo sapiens |
? | x * 78000, lens transglutaminase, SDS-PAGE | Oryctolagus cuniculus |