Literature summary for 2.3.2.13 extracted from

Jeon, J.H.; Lee, H.J.; Jang, G.Y.; Kim, C.W.; Shim, D.M.; Cho, S.Y.; Yeo, E.J.; Park, S.C.; Kim, I.G.
Different inhibition characteristics of intracellular transglutaminase activity by cystamine and cysteamine (2004), Exp. Mol. Med., 36, 576-581.

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Activating Compound

Activating Compound	Comment	Organism	Structure
dithiothreitol	3.8fold increase in activity at 10 mM	Homo sapiens
glutathione	reduced, 2.7fold increase in activity at 5 mM	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
cystamine	50% inhibition at 0.022 mM	Homo sapiens
cysteamine	50% inhibition at 0.178 mM	Homo sapiens
additional information	inhibitory activity in decreasing order: cystamine, spermidine, spermine, putrescine, cysteamine	Homo sapiens
putrescine	-	Homo sapiens
spermidine	-	Homo sapiens
spermine	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	expression in baculovirus system	-

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Release 2023.1 (January 2023)