Literature summary for 2.3.2.13 extracted from

Shin, D.M.; Jeon, J.H.; Kim, C.W.; Cho, S.Y.; Kwon, J.C.; Lee, H.J.; Choi, K.H.; Park, S.C.; Kim, I.G.
Cell Type-specific activation of intracellular transglutaminase 2 by oxidative stress or ultraviolet irradiation: implications of transglutaminase 2 in age-related cataractogenesis (2004), J. Biol. Chem., 279, 15032-15039.

Search for more literature for 2.3.2.13

Application

Application	Comment	Organism
medicine	involvement of enzyme in age-related cataractogenesis	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	enzyme may be involved in cataractogenesis	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	enzyme activity is elevated after oxidative stress or UV irradiation. Intrinsic activity or activation of enzyme is cell-type specific and does not correlate with enzyme expression level	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
A-549 cell	lung cancer cell line	Homo sapiens	-
HLE B-3 cell	lens epithelial cell line	Homo sapiens	-
K-562 cell	leukemia cell line	Homo sapiens	-
MCF-7 cell	breast cancer cell line	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
alphaB-crystallin + ?	-	Homo sapiens	?	formation of water-insoluble dimers or polymers	?
betaB2-crystallin + ?	-	Homo sapiens	?	formation of water-insoluble dimers or polymers	?
additional information	enzyme may be involved in cataractogenesis	Homo sapiens	?	-	?
vimentin + ?	-	Homo sapiens	?	formation of water-insoluble dimers or polymers	?

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Release 2023.1 (January 2023)