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Literature summary for 2.3.2.13 extracted from

  • Curro, M.; Gangemi, C.; Gugliandolo, A.; Risitano, R.; Ferlazzo, N.; Ientile, R.; Caccamo, D.
    Transglutaminase 2 is involved in homocysteine-induced activation of human THP-1 monocytes (2015), Free Radic. Res., 49, 299-308.
    View publication on PubMed
Search for more literature for 2.3.2.13

Inhibitors

Inhibitors Comment Organism Structure
R283 specific inhibitor, i.e. 1,3-dimethyl-2-[(2-oxopropyl)thio]imidazolium chloride, complete inhibition at 0.25 mM Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
80000
-
 x * 80000, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
monocyte
-
 Homo sapiens
-
THP-1 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[protein]-gamma-glutamine + 5-(biotinamido) pentylamine
-
 Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
? x * 80000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
TG2
-
 Homo sapiens
transglutaminase 2
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the enzyme plays a key role in homocysteine-induced activation of THP-1 monocytes, involving oxidative as well as endoplasmic resticulum stress and inflammation up

General Information

General Information Comment Organism
physiological function transglutaminase 2 is involved in homocysteine-induced activation of human THP-1 monocytes Homo sapiens