Literature summary for 2.3.2.15 extracted from

Vatamaniuk, O.K.; Bucher, E.A.; Ward, J.T.; Rea, P.A.
A new pathway for heavy metal detoxification in animals. Phytochelatin synthase is required for cadmium tolerance in Caenorhabditis elegans (2001), J. Biol. Chem., 276, 20817-20820.

Search for more literature for 2.3.2.15

Cloned(Commentary)

Cloned (Comment)	Organism
transformed into Saccharomyces cerevisiae strain DTY67, hypersensitive to Cd2+-stress	Caenorhabditis elegans

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
glutathione + [Glu(-Cys)]n-Gly	Caenorhabditis elegans	critical for heavy metal tolerance	Gly + [Glu(-Cys)]n+1-Gly	-	?
glutathione + [Glu(-Cys)]n-Gly	Caenorhabditis elegans N2	critical for heavy metal tolerance	Gly + [Glu(-Cys)]n+1-Gly	-	?

Organism

Organism	UniProt	Comment	Textmining
Caenorhabditis elegans	G5ECE4	-	-
Caenorhabditis elegans N2	G5ECE4	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
glutathione + [Glu(-Cys)]n-Gly	critical for heavy metal tolerance	Caenorhabditis elegans	Gly + [Glu(-Cys)]n+1-Gly	-	?
glutathione + [Glu(-Cys)]n-Gly	critical for heavy metal tolerance	Caenorhabditis elegans N2	Gly + [Glu(-Cys)]n+1-Gly	-	?

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Release 2023.1 (January 2023)