Inhibitors | Comment | Organism | Structure |
---|---|---|---|
acivicin | - |
Ascaris suum | |
D-serine | - |
Ascaris suum | |
L- or D-Serine/borate | competitive | Ascaris suum | |
L-(alphaS,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazolacetic acid | i.e. acivicin; in vivo inhibition and accumulation of glutathione; kinetics; strong, irreversible, reacts with glutamyl binding site | Ascaris suum | |
L-serine | - |
Ascaris suum |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | kinetic study | Ascaris suum | |
additional information | - |
additional information | Km values for several amino acids and dipeptides, overview | Ascaris suum | |
0.03 | - |
5-L-glutamyl-7-amido-4-methylcoumarin | - |
Ascaris suum | |
1.28 | - |
glycylglycine | - |
Ascaris suum |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Ascaris suum | 16020 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
30000 | - |
1 * 43000 + 1 * 30000, SDS-PAGE | Ascaris suum |
43000 | - |
1 * 43000 + 1 * 30000, SDS-PAGE | Ascaris suum |
70000 | - |
gel filtration | Ascaris suum |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(5-L-glutamyl)-peptide + acceptor + H+ | Ascaris suum | - |
peptide + 5-L-glutamyl amino acid | - |
? | |
glutathione + an amino acid | Ascaris suum | initial step of glutathione degradation | L-cysteinylglycine + a 5-L-glutamyl-amino acid | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Ascaris suum | - |
- |
- |
Purification (Comment) | Organism |
---|---|
solubilized by Triton X-100 | Ascaris suum |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
a (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acid | kinetic study | Ascaris suum |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
activities with diverse substrates | Ascaris suum |
1009 | - |
purified enzyme | Ascaris suum |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(5-L-glutamyl)-peptide + acceptor + H+ | - |
Ascaris suum | peptide + 5-L-glutamyl amino acid | - |
? | |
(5-L-glutamyl)-peptide + acceptor + H+ | acceptor specificity, overview | Ascaris suum | peptide + 5-L-glutamyl amino acid | - |
? | |
5-L-glutamyl-7-amido-4-methylcoumarin + acceptor | acceptors are amino acids and peptides, overview | Ascaris suum | 7-amino-4-methylcoumarin + 5-L-glutamyl-acceptor | - |
? | |
5-L-glutamyl-7-amido-4-methylcoumarin + acceptor | glycylglycine is best acceptor | Ascaris suum | 7-amino-4-methylcoumarin + 5-L-glutamyl-acceptor | - |
? | |
glutathione + an amino acid | initial step of glutathione degradation | Ascaris suum | L-cysteinylglycine + a 5-L-glutamyl-amino acid | - |
? | |
L-glutamyl-gamma-7-amido-4-methylcoumarin + glycylglycine | - |
Ascaris suum | 7-amino-4-methylcoumarin + L-glutamyl-glycylglycine | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 1 * 43000 + 1 * 30000, SDS-PAGE | Ascaris suum |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Ascaris suum |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.5 | - |
assay at | Ascaris suum |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.3 | - |
L-serine | in presence of borate | Ascaris suum | |
0.42 | - |
acivicin | - |
Ascaris suum | |
0.61 | - |
D-serine | in presence of borate | Ascaris suum |