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Literature summary for 2.3.2.5 extracted from

  • Busby, W.H.; Quackenbush, G.E.; Humm, J.; Youngblood, W.W.; Kizer, J.S.
    An enzyme(s) that converts glutaminyl-peptides into pyroglutamyl-peptides. Presence in pituitary, brain, adrenal medulla, and lymphocytes (1987), J. Biol. Chem., 262, 8532-8536.
    View publication on PubMed
Search for more literature for 2.3.2.5

Activating Compound

Activating Compound Comment Organism Structure
EDTA stimulates Sus scrofa

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline 2 mM, complete inhibition Sus scrofa
6-methylpterin
-
 Sus scrofa
ascorbate
-
 Sus scrofa
CuCl2 0.1 mM Sus scrofa
FADH2 2 mM Sus scrofa
NEM
-
 Sus scrofa
NiCl2 0.1 mM Sus scrofa
ZnCl2 0.1 mM Sus scrofa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information
-
 Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
chromaffin granule
-
 Bos taurus 42583
-
vesicular fraction
-
 Bos taurus
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
55000
-
 gel filtration Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-glutaminyl-peptide Homo sapiens involved in posttranslational modification of the N-terminal glutamine of peptide hormones or neurotransmitters, such as thyrotropin releasing hormone, luteinizing hormone releasing hormone, gastrin, heavy chain of gamma-globulin 5-oxoprolyl-peptide + NH3
-
 ?
L-glutaminyl-peptide Rattus norvegicus involved in posttranslational modification of the N-terminal glutamine of peptide hormones or neurotransmitters, such as thyrotropin releasing hormone, luteinizing hormone releasing hormone, gastrin, heavy chain of gamma-globulin 5-oxoprolyl-peptide + NH3
-
 ?
L-glutaminyl-peptide Sus scrofa involved in posttranslational modification of the N-terminal glutamine of peptide hormones or neurotransmitters, such as thyrotropin releasing hormone, luteinizing hormone releasing hormone, gastrin, heavy chain of gamma-globulin 5-oxoprolyl-peptide + NH3
-
 ?
L-glutaminyl-peptide Bos taurus involved in posttranslational modification of the N-terminal glutamine of peptide hormones or neurotransmitters, such as thyrotropin releasing hormone, luteinizing hormone releasing hormone, gastrin, heavy chain of gamma-globulin 5-oxoprolyl-peptide + NH3
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Homo sapiens
-
-
-
Rattus norvegicus
-
 neonatal
-
Sus scrofa
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
-
 Homo sapiens
glycoprotein
-
 Rattus norvegicus
glycoprotein
-
 Sus scrofa
glycoprotein
-
 Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
adrenal medulla
-
 Bos taurus
-
B-lymphocyte secretory and non-secretory cell line P3X63Ag8 Homo sapiens
-
brain
-
 Rattus norvegicus
-
brain
-
 Bos taurus
-
pituitary gland
-
 Homo sapiens
-
pituitary gland
-
 Sus scrofa
-
pituitary gland
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-glutaminyl-peptide thyrotropin-releasing hormone Homo sapiens 5-oxoprolyl-peptide + NH3
-
 ?
L-glutaminyl-peptide thyrotropin-releasing hormone Rattus norvegicus 5-oxoprolyl-peptide + NH3
-
 ?
L-glutaminyl-peptide thyrotropin-releasing hormone Sus scrofa 5-oxoprolyl-peptide + NH3
-
 ?
L-glutaminyl-peptide thyrotropin-releasing hormone Bos taurus 5-oxoprolyl-peptide + NH3
-
 ?
L-glutaminyl-peptide involved in posttranslational modification of the N-terminal glutamine of peptide hormones or neurotransmitters, such as thyrotropin releasing hormone, luteinizing hormone releasing hormone, gastrin, heavy chain of gamma-globulin Homo sapiens 5-oxoprolyl-peptide + NH3
-
 ?
L-glutaminyl-peptide involved in posttranslational modification of the N-terminal glutamine of peptide hormones or neurotransmitters, such as thyrotropin releasing hormone, luteinizing hormone releasing hormone, gastrin, heavy chain of gamma-globulin Rattus norvegicus 5-oxoprolyl-peptide + NH3
-
 ?
L-glutaminyl-peptide involved in posttranslational modification of the N-terminal glutamine of peptide hormones or neurotransmitters, such as thyrotropin releasing hormone, luteinizing hormone releasing hormone, gastrin, heavy chain of gamma-globulin Sus scrofa 5-oxoprolyl-peptide + NH3
-
 ?
L-glutaminyl-peptide involved in posttranslational modification of the N-terminal glutamine of peptide hormones or neurotransmitters, such as thyrotropin releasing hormone, luteinizing hormone releasing hormone, gastrin, heavy chain of gamma-globulin Bos taurus 5-oxoprolyl-peptide + NH3
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2 7.5
-
 Sus scrofa