Literature summary for 2.3.3.10 extracted from

Greenspan, M.D.; Yudkovitz, J.B.; Lo, C.Y.L.; Chen, J.S.; Alberts, A.W.; Hunt, V.M.; Chang, M.N.; Yang, S.S.; Thompson, K.L.; Chiang, Y.C.P.; Chabala, J.C.; Monaghan, R.L.; Schwartz, R.L.
Inhibition of hydroxymethylglutaryl-coenzyme A synthase by L659,699 (1987), Proc. Natl. Acad. Sci. USA, 84, 7488-7492.

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Inhibitors

Inhibitors	Comment	Organism	Structure
(E,E)-11-[3-(hydroxymethyl)-4-oxo-2-oxytanyl]-3,5,7-trimethyl-2,4-undecadienenoic acid	-	Homo sapiens
(E,E)-11-[3-(hydroxymethyl)-4-oxo-2-oxytanyl]-3,5,7-trimethyl-2,4-undecadienenoic acid	-	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	-	Gallus gallus	5737	-
cytoplasm	-	Homo sapiens	5737	-
cytoplasm	-	Rattus norvegicus	5737	-
cytosol	-	Gallus gallus	5829	-
cytosol	-	Homo sapiens	5829	-
cytosol	-	Rattus norvegicus	5829	-
mitochondrion	-	Gallus gallus	5739	-
mitochondrion	-	Homo sapiens	5739	-
mitochondrion	-	Rattus norvegicus	5739	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
acetyl-CoA + acetoacetyl-CoA + H2O	Gallus gallus	-	(S)-3-hydroxy-3-methylglutaryl-CoA + CoA	-	?
acetyl-CoA + acetoacetyl-CoA + H2O	Cricetulus griseus	-	(S)-3-hydroxy-3-methylglutaryl-CoA + CoA	-	?
acetyl-CoA + acetoacetyl-CoA + H2O	Homo sapiens	-	(S)-3-hydroxy-3-methylglutaryl-CoA + CoA	-	?
acetyl-CoA + acetoacetyl-CoA + H2O	Rattus norvegicus	first committed step in isoprenoid biosynthesis	(S)-3-hydroxy-3-methylglutaryl-CoA + CoA	-	?

Organism

Organism	UniProt	Comment	Textmining
Cricetulus griseus	-	chinese hamster	-
Gallus gallus	-	chicken	-
Homo sapiens	-	HeLa cells	-
Rattus norvegicus	-	rat	-

Purification (Commentary)

Purification (Comment)	Organism
partially	Rattus norvegicus

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Gallus gallus	-
liver	-	Rattus norvegicus	-
ovary	-	Cricetulus griseus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acetyl-CoA + acetoacetyl-CoA + H2O	-	Gallus gallus	(S)-3-hydroxy-3-methylglutaryl-CoA + CoA	-	?
acetyl-CoA + acetoacetyl-CoA + H2O	-	Cricetulus griseus	(S)-3-hydroxy-3-methylglutaryl-CoA + CoA	-	?
acetyl-CoA + acetoacetyl-CoA + H2O	-	Homo sapiens	(S)-3-hydroxy-3-methylglutaryl-CoA + CoA	-	?
acetyl-CoA + acetoacetyl-CoA + H2O	-	Rattus norvegicus	(S)-3-hydroxy-3-methylglutaryl-CoA + CoA	-	?
acetyl-CoA + acetoacetyl-CoA + H2O	first committed step in isoprenoid biosynthesis	Rattus norvegicus	(S)-3-hydroxy-3-methylglutaryl-CoA + CoA	-	?

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Release 2023.1 (January 2023)