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Literature summary for 2.3.3.10 extracted from

  • Andringa, K.K.; Bajt, M.L.; Jaeschke, H.; Bailey, S.M.
    Mitochondrial protein thiol modifications in acetaminophen hepatotoxicity: effect on HMG-CoA synthase (2008), Toxicol. Lett., 177, 188-197.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine acetaminophen, APAP, is a leading cause of drug-induced liver failure Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Mus musculus 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
56800
-
determined by MALDI-TOF mass spectrometry Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + H2O + acetoacetyl-CoA Mus musculus
-
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
ir

Organism

Organism UniProt Comment Textmining
Mus musculus P54869
-
-

Purification (Commentary)

Purification (Comment) Organism
mitochondria are prepared Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Mus musculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.035
-
activity in response to acetaminophen, APAP, treatment Mus musculus
0.057
-
control, no acetaminophen, APAP, treatment Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + H2O + acetoacetyl-CoA
-
Mus musculus (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
ir

Synonyms

Synonyms Comment Organism
3-hydroxy-3-methylglutaryl-CoA synthase 2
-
Mus musculus
HMG-CoA synthase
-
Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
activity assay Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.2
-
activity assay Mus musculus

Cofactor

Cofactor Comment Organism Structure
CoA
-
Mus musculus

Expression

Organism Comment Expression
Mus musculus 3-hydroxy-3-methylglutaryl-CoA synthase 2 has significantly decreased levels of reduced thiols and activity after acetaminophen treatment down