Application | Comment | Organism |
---|---|---|
medicine | acetaminophen, APAP, is a leading cause of drug-induced liver failure | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Mus musculus | 5739 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
56800 | - |
determined by MALDI-TOF mass spectrometry | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + H2O + acetoacetyl-CoA | Mus musculus | - |
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
ir |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P54869 | - |
- |
Purification (Comment) | Organism |
---|---|
mitochondria are prepared | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Mus musculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.035 | - |
activity in response to acetaminophen, APAP, treatment | Mus musculus |
0.057 | - |
control, no acetaminophen, APAP, treatment | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + H2O + acetoacetyl-CoA | - |
Mus musculus | (S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
ir |
Synonyms | Comment | Organism |
---|---|---|
3-hydroxy-3-methylglutaryl-CoA synthase 2 | - |
Mus musculus |
HMG-CoA synthase | - |
Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
activity assay | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.2 | - |
activity assay | Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
CoA | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | 3-hydroxy-3-methylglutaryl-CoA synthase 2 has significantly decreased levels of reduced thiols and activity after acetaminophen treatment | down |