Literature summary for 2.3.3.13 extracted from

de Carvalho, L.P.S.; Argyrou, A.; Blanchard, J.S.
Slow-onset feedback inhibition: Inhibition of Mycobacterium tuberculosis alpha-isopropylmalate synthase by L-leucine (2005), J. Am. Chem. Soc., 127, 10004-10005.

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Inhibitors

Inhibitors	Comment	Organism	Structure
L-leucine	linear, non-competitive feedback inhibition	Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
acetyl-CoA + alpha-ketoisovalerate + H2O	Mycobacterium tuberculosis	first step of leucine biosynthesis	alpha-isopropylmalate + CoA	-	?

Organism

Organism	UniProt	Comment	Textmining
Mycobacterium tuberculosis	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acetyl-CoA + alpha-ketoisovalerate + H2O	first step of leucine biosynthesis	Mycobacterium tuberculosis	alpha-isopropylmalate + CoA	-	?
acetyl-CoA + alpha-ketoisovalerate + H2O	aldol condensation reaction	Mycobacterium tuberculosis	alpha-isopropylmalate + CoA	-	?

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.017	-	L-leucine	-	Mycobacterium tuberculosis

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Release 2023.1 (January 2023)