Cloned (Comment) | Organism |
---|---|
overexpression in Penicillium chrysogenum using additional copies of lys1 with its own promoter or under the control of the pcbC promoter in either autonomously replicating or integrative vectors. Tranformants containing 3 to 32 additional copies of the lys1 gene are selected | Penicillium chrysogenum |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + H2O + 2-oxoglutarate | Penicillium chrysogenum | the enzyme catalyzes the first step of the lysine and penicillin pathway and is highly sensitive to feedback regulation by L-lysine | 2-hydroxybutane-1,2,4-tricarboxylate + CoA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Penicillium chrysogenum | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + H2O + 2-oxoglutarate | - |
Penicillium chrysogenum | 2-hydroxybutane-1,2,4-tricarboxylate + CoA | - |
? | |
acetyl-CoA + H2O + 2-oxoglutarate | the enzyme catalyzes the first step of the lysine and penicillin pathway and is highly sensitive to feedback regulation by L-lysine | Penicillium chrysogenum | 2-hydroxybutane-1,2,4-tricarboxylate + CoA | - |
? |