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Literature summary for 2.3.3.14 extracted from

  • Andi, B.; West, A.H.; Cook, P.F.
    Kinetic mechanism of histidine-tagged homocitrate synthase from Saccharomyces cerevisiae (2004), Biochemistry, 43, 11790-11795.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
citrate competitive versus 2-oxoglutarate; noncompetitive Saccharomyces cerevisiae
CoA noncompetitive versus acetyl-CoA Saccharomyces cerevisiae
desulfo-CoA uncompetitive Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + H2O + 2-oxoglutarate sequential ordered kinetic mechanism for the histidine-tagged enzyme with 2-oxoglutarate binding before acetyl-CoA and CoA released before homocitrate Saccharomyces cerevisiae 2-hydroxybutane-1,2,4-tricarboxylate + CoA
-
ir
acetyl-CoA + H2O + oxaloacetate oxaloacetate is a substrate with lower affinity than 2-oxoglutarate Saccharomyces cerevisiae ? + CoA
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.008
-
CoA Kis, varied substrate acetyl-CoA, fixed substrate: 5 mM 2-oxoglutarate Saccharomyces cerevisiae
0.014
-
desulfo-CoA Kis, varied substrate acetyl-CoA, fixed substrate: 5 mM 2-oxoglutarate Saccharomyces cerevisiae
0.021
-
desulfo-CoA Kii, varied substrate 2-oxoglutarate, fixed substrate: 0.031 mM acteyl-CoA Saccharomyces cerevisiae
0.024
-
CoA Kii, varied substrate 2-oxoglutarate, fixed substrate: 0.031 mM acetyl-CoA Saccharomyces cerevisiae
0.033
-
CoA Kii, varied substrate acetyl-CoA, fixed substrate: 5 mM 2-oxoglutarate Saccharomyces cerevisiae
0.18
-
desulfo-CoA Kii, varied substrate acetyl-CoA, fixed substrate: 5 mM 2-oxoglutarate Saccharomyces cerevisiae
13.5
-
citrate Kis, varied substrate is 2-oxoglutarate, fixed substrate: 0.031 mM acetyl-CoA Saccharomyces cerevisiae
19
-
citrate Kis, varied substrate is acetyl-CoA, fixed substrate: 5 mM 2-oxoglutarate Saccharomyces cerevisiae
200
-
citrate Kii, varied substrate is acetyl-CoA, fixed substrate: 5 mM 2-oxoglutarate Saccharomyces cerevisiae