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Literature summary for 2.3.3.14 extracted from

  • Suzuki, T.; Akiyama, N.; Yoshida, A.; Tomita, T.; Lassak, K.; Haurat, M.F.; Okada, T.; Takahashi, K.; Albers, S.V.; Kuzuyama, T.; Nishiyama, M.
    Biochemical characterization of archaeal homocitrate synthase from Sulfolobus acidocaldarius (2020), FEBS Lett., 594, 126-134 .
    View publication on PubMed
Search for more literature for 2.3.3.14

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Sulfolobus acidocaldarius

Protein Variants

Protein Variants Comment Organism
additional information the RAM domain is responsible for enzyme inhibition. A mutant enzyme lacking the RAM domain is insensitive to inhibition by lysine Sulfolobus acidocaldarius

Inhibitors

Inhibitors Comment Organism Structure
lysine mutant enzyme lacking the RAM domain is insensitive to inhibition by lysine Sulfolobus acidocaldarius

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + H2O + 2-oxoglutarate Sulfolobus acidocaldarius the enzyme catalyzes the first and committed step of the alpha-aminoadipate pathway (2R)-2-hydroxybutane-1,2,4-tricarboxylate + CoA
-
 ?
acetyl-CoA + H2O + 2-oxoglutarate Sulfolobus acidocaldarius DSM 639 the enzyme catalyzes the first and committed step of the alpha-aminoadipate pathway (2R)-2-hydroxybutane-1,2,4-tricarboxylate + CoA
-
 ?

Organism

Organism UniProt Comment Textmining
Sulfolobus acidocaldarius Q4J989
-
-
Sulfolobus acidocaldarius DSM 639 Q4J989
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + H2O + 2-oxoglutarate
-
 Sulfolobus acidocaldarius (2R)-2-hydroxybutane-1,2,4-tricarboxylate + CoA
-
 ?
acetyl-CoA + H2O + 2-oxoglutarate the enzyme catalyzes the first and committed step of the alpha-aminoadipate pathway Sulfolobus acidocaldarius (2R)-2-hydroxybutane-1,2,4-tricarboxylate + CoA
-
 ?
acetyl-CoA + H2O + 2-oxoglutarate
-
 Sulfolobus acidocaldarius DSM 639 (2R)-2-hydroxybutane-1,2,4-tricarboxylate + CoA
-
 ?
acetyl-CoA + H2O + 2-oxoglutarate the enzyme catalyzes the first and committed step of the alpha-aminoadipate pathway Sulfolobus acidocaldarius DSM 639 (2R)-2-hydroxybutane-1,2,4-tricarboxylate + CoA
-
 ?

Synonyms

Synonyms Comment Organism
saci_1304
-
 Sulfolobus acidocaldarius

General Information

General Information Comment Organism
metabolism the enzyme catalyzes the first and committed step of the alpha-aminoadipate pathway Sulfolobus acidocaldarius