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Literature summary for 2.3.3.8 extracted from

  • Houston, B.; Nimmo, H.G.
    Purification and some kinetic properties of rat liver ATP citrate lyase (1984), Biochem. J., 224, 437-443.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.3.8

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
123000
-
 x * 123000, SDS-PAGE Rattus norvegicus
500000
-
 non-denaturing PAGE Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + citrate + CoA Rattus norvegicus the enzyme catalyzes the first cytoplasmic step in the synthesis of long-chain fatty acids in mammalian tissues ADP + phosphate + acetyl-CoA + oxaloacetate
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
liver enzyme Rattus norvegicus

Reaction

Reaction Comment Organism Reaction ID
ADP + phosphate + acetyl-CoA + oxaloacetate = ATP + citrate + CoA double-displacement mechanism with a phosphoenzyme intermediate Rattus norvegicus
a

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
13.6
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + citrate + CoA
-
 Rattus norvegicus ADP + phosphate + acetyl-CoA + oxaloacetate
-
 ?
ATP + citrate + CoA the enzyme catalyzes the first cytoplasmic step in the synthesis of long-chain fatty acids in mammalian tissues Rattus norvegicus ADP + phosphate + acetyl-CoA + oxaloacetate
-
 ?

Subunits

Subunits Comment Organism
? x * 123000, SDS-PAGE Rattus norvegicus