Literature summary for 2.3.3.8 extracted from

Bazilevsky, G.A.; Affronti, H.C.; Wei, X.; Campbell, S.L.; Wellen, K.E.; Marmorstein, R.
ATP-citrate lyase multimerization is required for coenzyme-A substrate binding and catalysis (2019), J. Biol. Chem., 294, 7259-7268 .

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + citrate + CoA	Homo sapiens	the enzyme is a major source of nucleocytosolic acetyl-CoA, a fundamental building block of carbon metabolism in eukaryotes	ADP + phosphate + acetyl-CoA + oxaloacetate	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P53396	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + citrate + CoA	-	Homo sapiens	ADP + phosphate + acetyl-CoA + oxaloacetate	-	?
ATP + citrate + CoA	the enzyme is a major source of nucleocytosolic acetyl-CoA, a fundamental building block of carbon metabolism in eukaryotes	Homo sapiens	ADP + phosphate + acetyl-CoA + oxaloacetate	-	?

Subunits

Subunits	Comment	Organism
tetramer	ACLY C-terminal citrate synthase homology domain maintains ACLY tetramerization, a conserved and essential quaternary structure. ATP-citrate lyase multimerization is required for coenzyme-A substrate binding and catalysis	Homo sapiens

Synonyms

Synonyms	Comment	Organism
ACLY	-	Homo sapiens
ATP-citrate lyase	-	Homo sapiens

General Information

General Information	Comment	Organism
metabolism	the enzyme is a major source of nucleocytosolic acetyl-CoA, a fundamental building block of carbon metabolism in eukaryotes	Homo sapiens

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Release 2023.1 (January 2023)