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Literature summary for 2.4.1.1 extracted from

  • Tsirkone, V.G.; Tsoukala, E.; Lamprakis, C.; Manta, S.; Hayes, J.M.; Skamnaki, V.T.; Drakou, C.; Zographos, S.E.; Komiotis, D.; Leonidas, D.D.
    1-(3-Deoxy-3-fluoro-beta-D-glucopyranosyl) pyrimidine derivatives as inhibitors of glycogen phosphorylase b: kinetic, crystallographic and modelling studies (2010), Bioorg. Med. Chem., 18, 3413-3425.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
AMP
-
Oryctolagus cuniculus

Crystallization (Commentary)

Crystallization (Comment) Organism
purified enzyme bound to different inhibitors, X-ray diffraction structure determination and analysis at 1.9-2.0 A resolution, structure modeling Oryctolagus cuniculus

Inhibitors

Inhibitors Comment Organism Structure
additional information inhibitor screening, native ligand docking of inhibitor tautomers supplemented by QM/MM calculations, modeling of free state ligands and bound ligands, detailed overview Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[(1->4)-alpha-D-glucosyl]n + phosphate Oryctolagus cuniculus
-
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
r

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
muscle
-
Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[(1->4)-alpha-D-glucosyl]n + phosphate
-
Oryctolagus cuniculus [(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
r

Synonyms

Synonyms Comment Organism
glycogen phosphorylase b
-
Oryctolagus cuniculus
GPb
-
Oryctolagus cuniculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.8
-
assay at Oryctolagus cuniculus