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Literature summary for 2.4.1.1 extracted from

  • Cheng, K.; Liu, J.; Sun, H.; Xie, J.
    Synthesis of oleanolic acid dimers as inhibitors of glycogen phosphorylase (2010), Chem. Biodivers., 7, 690-697.
    View publication on PubMed
Search for more literature for 2.4.1.1

Activating Compound

Activating Compound Comment Organism Structure
AMP binds at the allosteric site Oryctolagus cuniculus

Inhibitors

Inhibitors Comment Organism Structure
(3beta,3'beta)-3,3'-[hexane-1,6-diylbis(1H-1,2,3-triazole-1,4-diylmethanediyloxy)]bisolean-12-en-28-oic acid
-
 Oryctolagus cuniculus
alpha-D-glucose 6-phosphate binds at the allosteric site Oryctolagus cuniculus
bis(6-([(3beta)-3-hydroxy-28-oxoolean-12-en-28-yl]oxy)hexyl) (2R)-2-hydroxybutanedioate
-
 Oryctolagus cuniculus
Caffeine
-
 Oryctolagus cuniculus
hexane-1,6-diylbis(1H-1,2,3-triazole-1,4-diylmethanediyl) (3beta,3'beta)-bis(3-hydroxyolean-12-en-28-oate)
-
 Oryctolagus cuniculus
iminobis[ethane-2,1-diylimino(3beta)-28-oxoolean-12-ene-28,3-diyl]diacetate
-
 Oryctolagus cuniculus
additional information the purine inhibitory site binds purine derivatives as well as pentacyclic triterpenes. Synthesis and inhibitory potencies of triazole-linked oleanolic acid dimers as enzyme inhibitors, overview. No inhibition by hexane-1,6-diyl(3beta,3'beta)-bis(3-hydroxyolean-12-en-28-oate) and dibenzyl (3beta,3'beta)-3,3'-[hexane-1,6-diylbis(1H-1,2,3-triazole-1,4-diylmethanediyloxy)]bisolean-12-en-28-oate Oryctolagus cuniculus
oleanolic acid a naturally existing pentacyclic triterpene Oryctolagus cuniculus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ activates Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[(1->4)-alpha-D-glucosyl]n + phosphate Oryctolagus cuniculus
-
 [(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
 r

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
muscle
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the catalytic site binds glucose 1-phosphate, glycogen, glucose, and glucose analogues Oryctolagus cuniculus ?
-
 ?
[(1->4)-alpha-D-glucosyl]n + phosphate
-
 Oryctolagus cuniculus [(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
 r

Synonyms

Synonyms Comment Organism
glycogen phosphorylase a
-
 Oryctolagus cuniculus
GPA
-
 Oryctolagus cuniculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
22
-
 assay at Oryctolagus cuniculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2
-
 assay at Oryctolagus cuniculus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00259
-
 pH 7.2, 22°C Oryctolagus cuniculus (3beta,3'beta)-3,3'-[hexane-1,6-diylbis(1H-1,2,3-triazole-1,4-diylmethanediyloxy)]bisolean-12-en-28-oic acid
0.00325
-
 pH 7.2, 22°C Oryctolagus cuniculus iminobis[ethane-2,1-diylimino(3beta)-28-oxoolean-12-ene-28,3-diyl]diacetate
0.0123
-
 pH 7.2, 22°C Oryctolagus cuniculus bis(6-([(3beta)-3-hydroxy-28-oxoolean-12-en-28-yl]oxy)hexyl) (2R)-2-hydroxybutanedioate
0.0207
-
 pH 7.2, 22°C Oryctolagus cuniculus hexane-1,6-diylbis(1H-1,2,3-triazole-1,4-diylmethanediyl) (3beta,3'beta)-bis(3-hydroxyolean-12-en-28-oate)
0.1023
-
 pH 7.2, 22°C Oryctolagus cuniculus Caffeine