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Literature summary for 2.4.1.1 extracted from

  • Begum, J.; Varga, G.; Docsa, T.; Gergely, P.; Hayes, J.; Juhasz, L.; Somsak, L.
    Computationally motivated synthesis and enzyme kinetic evaluation of N-(beta-D-glucopyranosyl)-1,2,4-triazolecarboxamides as glycogen phosphorylase inhibitors (2015), MedChemComm, 6, 80-89.
No PubMed abstract available
Search for more literature for 2.4.1.1

Inhibitors

Inhibitors Comment Organism Structure
D-glucose physiological inhibitor Oryctolagus cuniculus
additional information computationally motivated synthesis, using N-(2,3,4,6-tetra-O-acetyl-beta-D-glucopyranosyl)-tetrazole-5-carboxamide as starting material, and enzyme kinetic evaluation of N-(beta-D-glucopyranosyl)-1,2,4-triazolecarboxamides as glycogen phosphorylase inhibitors, overview. No inhibition by 3b and 4b. Ki values are calculated from the IC50 values by the ChengPrusoff equation: Ki = IC50/(1 + [S]/Km). Comparison of the relative energies of different tautomers and conformations of the 1,2,4-triazole for models of the N-(beta-D-glucopyranosyl)-1,2,4-triazolecarboxamides, quantum mechanics/molecular mechanics calculations and modeling. No inhibition by 3b and 4b Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[(1->4)-alpha-D-glucosyl]n + phosphate Oryctolagus cuniculus
-
 [(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
 r

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus P00489
-
-

Source Tissue

Source Tissue Comment Organism Textmining
skeletal muscle
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[(1->4)-alpha-D-glucosyl]n + phosphate
-
 Oryctolagus cuniculus [(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
 r

Synonyms

Synonyms Comment Organism
glycogen phosphorylase b
-
 Oryctolagus cuniculus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.7
-
 D-glucose pH and temperature not specified in the publication Oryctolagus cuniculus