Literature summary for 2.4.1.117 extracted from

Arroyo-Flores, B.L.; Rodriguez-Bonilla, J.; Villagomez-Castro, J.C.; Calvo-Mendez, C.; Flores-Carreon, A.; Lopez-Romero, E.
Biosynthesis of glycoproteins in Candida albicans: Activity of mannosyl and glucosyl transferases (2000), Fungal Genet. Biol., 30, 127-133.

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Inhibitors

Inhibitors	Comment	Organism	Structure
Amphomycin	IC50 0.04 mM	Candida albicans
Ca2+	slight inhibition	Candida albicans
Mn2+	slight inhibition	Candida albicans
UMP	-	Candida albicans

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.05	-	UDP-glucose	-	Candida albicans

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Ca2+	no stimulation	Candida albicans
Mg2+	Mg2+ required, not Mn2+, Ca2+	Candida albicans
Mn2+	no stimulation	Candida albicans

Organism

Organism	UniProt	Comment	Textmining
Candida albicans	-	strain ATCC 26555	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
UDP-glucose + dolichyl phosphate	-	Candida albicans	UDP + dolichyl beta-D-glucosyl phosphate	-	?

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
28	-	-	Candida albicans

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.5	-	Tris/HCl buffer	Candida albicans

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.3	-	UMP	-	Candida albicans

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.04	-	IC50 0.04 mM	Candida albicans	Amphomycin

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Release 2023.1 (January 2023)