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Literature summary for 2.4.1.15 extracted from
- Role of trehalose phosphate synthase and trehalose during hypoxia: from flies to mammals (2004), J. Exp. Biol., 207, 3125-3129.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| DNA and amino acid sequence determination and analysis, overexpression in transgenic flies, functional expression in HEK-293 cells | Drosophila melanogaster |
| functional expression of the enzyme as a fusion protein with Escherichia coli trehalose-6-phosphate phosphatase in transgenic Oryza sativa plants, expression in human fibroblasts | Escherichia coli |
| overexpression of the enzyme incresases stress resistance of yeast cells | Schizosaccharomyces pombe |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | construction of transgenic Oryza sativa plants expressing the catalytically active enzyme as a fusion protein with trehalose-6-phosphate phosphatase of Escherichia coli under control of the ubiquitin promotor from Zea mays, the transgenic plants produce high levels of trehalose in seeds and leaves, carbohydrate profile of seeds, but not of leaves, is altered, plants show no growth inhibition or altered phenotype, expression in human fibroblasts renders the cells less sensitive to drought compared to wild-type cells | Escherichia coli |
| additional information | overexpression of the enzyme in flies increases their tolerance to anoxia and shortens the recovery time | Drosophila melanogaster |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Escherichia coli | trehalose is able to protect the integrity of the cells against a variety of environmental stresses such as desiccation, dehydration, heat, cold, and oxidation, probably via reduction of protein denaturation through protein-trehalose interactions | ? | - |
? |  |
| additional information | Schizosaccharomyces pombe | trehalose is able to protect the integrity of the cells against a variety of environmental stresses such as desiccation, dehydration, heat, cold, and oxidation, probably via reduction of protein denaturation through protein-trehalose interactions | ? | - |
? | |
| additional information | Drosophila melanogaster | trehalose is able to protect the integrity of the cells against a variety of environmental stresses such as desiccation, dehydration, heat, cold, and oxidation, probably via reduction of protein denaturation through protein-trehalose interactions, in flying insects trehalose content is especially high in hemolymph and thorax muscles and is consumed during flight | ? | - |
? | |
| additional information | Saccharomyces cerevisiae | trehalose is able to protect the integrity of the cells against a variety of environmental stresses such as desiccation, dehydration, heat, cold, and oxidation, probably via reduction of protein denaturation through protein-trehalose interactions, the enzyme might be a radical scavenger | ? | - |
? | |
| additional information | Candida albicans | trehalose is able to protect the integrity of the cells against a variety of environmental stresses such as desiccation, dehydration, heat, cold, and oxidation, probably via reduction of protein denaturation through protein-trehalose interactions, the enzyme might be a radical scavenger | ? | - |
? | |
| UDP-alpha-D-glucose + D-glucose 6-phosphate | Escherichia coli | step in trehalose biosynthesis | UDP + alpha,alpha-trehalose 6-phosphate | - |
? | |
| UDP-alpha-D-glucose + D-glucose 6-phosphate | Saccharomyces cerevisiae | step in trehalose biosynthesis | UDP + alpha,alpha-trehalose 6-phosphate | - |
? | |
| UDP-alpha-D-glucose + D-glucose 6-phosphate | Schizosaccharomyces pombe | step in trehalose biosynthesis | UDP + alpha,alpha-trehalose 6-phosphate | - |
? | |
| UDP-alpha-D-glucose + D-glucose 6-phosphate | Candida albicans | step in trehalose biosynthesis | UDP + alpha,alpha-trehalose 6-phosphate | - |
? | |
| UDP-alpha-D-glucose + D-glucose 6-phosphate | Drosophila melanogaster | step in trehalose biosynthesis | UDP + alpha,alpha-1,1-trehalose 6-phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Candida albicans | - |
- |
- |
| Drosophila melanogaster | - |
gene tps1 | - |
| Escherichia coli | - |
gene otsA | - |
| Saccharomyces cerevisiae | - |
- |
- |
| Schizosaccharomyces pombe | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | trehalose is able to protect the integrity of the cells against a variety of environmental stresses such as desiccation, dehydration, heat, cold, and oxidation, probably via reduction of protein denaturation through protein-trehalose interactions | Escherichia coli | ? | - |
? | |
| additional information | trehalose is able to protect the integrity of the cells against a variety of environmental stresses such as desiccation, dehydration, heat, cold, and oxidation, probably via reduction of protein denaturation through protein-trehalose interactions | Schizosaccharomyces pombe | ? | - |
? | |
| additional information | trehalose is able to protect the integrity of the cells against a variety of environmental stresses such as desiccation, dehydration, heat, cold, and oxidation, probably via reduction of protein denaturation through protein-trehalose interactions, in flying insects trehalose content is especially high in hemolymph and thorax muscles and is consumed during flight | Drosophila melanogaster | ? | - |
? | |
| additional information | trehalose is able to protect the integrity of the cells against a variety of environmental stresses such as desiccation, dehydration, heat, cold, and oxidation, probably via reduction of protein denaturation through protein-trehalose interactions, the enzyme might be a radical scavenger | Saccharomyces cerevisiae | ? | - |
? | |
| additional information | trehalose is able to protect the integrity of the cells against a variety of environmental stresses such as desiccation, dehydration, heat, cold, and oxidation, probably via reduction of protein denaturation through protein-trehalose interactions, the enzyme might be a radical scavenger | Candida albicans | ? | - |
? | |
| UDP-alpha-D-glucose + D-glucose 6-phosphate | - |
Drosophila melanogaster | UDP + alpha,alpha-trehalose 6-phosphate | - |
? | |
| UDP-alpha-D-glucose + D-glucose 6-phosphate | - |
Escherichia coli | UDP + alpha,alpha-trehalose 6-phosphate | - |
? | |
| UDP-alpha-D-glucose + D-glucose 6-phosphate | - |
Saccharomyces cerevisiae | UDP + alpha,alpha-trehalose 6-phosphate | - |
? | |
| UDP-alpha-D-glucose + D-glucose 6-phosphate | - |
Schizosaccharomyces pombe | UDP + alpha,alpha-trehalose 6-phosphate | - |
? | |
| UDP-alpha-D-glucose + D-glucose 6-phosphate | - |
Candida albicans | UDP + alpha,alpha-trehalose 6-phosphate | - |
? | |
| UDP-alpha-D-glucose + D-glucose 6-phosphate | step in trehalose biosynthesis | Escherichia coli | UDP + alpha,alpha-trehalose 6-phosphate | - |
? | |
| UDP-alpha-D-glucose + D-glucose 6-phosphate | step in trehalose biosynthesis | Saccharomyces cerevisiae | UDP + alpha,alpha-trehalose 6-phosphate | - |
? | |
| UDP-alpha-D-glucose + D-glucose 6-phosphate | step in trehalose biosynthesis | Schizosaccharomyces pombe | UDP + alpha,alpha-trehalose 6-phosphate | - |
? | |
| UDP-alpha-D-glucose + D-glucose 6-phosphate | step in trehalose biosynthesis | Candida albicans | UDP + alpha,alpha-trehalose 6-phosphate | - |
? | |
| UDP-alpha-D-glucose + D-glucose 6-phosphate | step in trehalose biosynthesis | Drosophila melanogaster | UDP + alpha,alpha-1,1-trehalose 6-phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| TPS1 | - |
Drosophila melanogaster |
| TPS1 | - |
Escherichia coli |
| TPS1 | - |
Saccharomyces cerevisiae |
| TPS1 | - |
Schizosaccharomyces pombe |
| TPS1 | - |
Candida albicans |
| trehalose-6-phosphate synthase | - |
Drosophila melanogaster |
| trehalose-6-phosphate synthase | - |
Escherichia coli |
| trehalose-6-phosphate synthase | - |
Saccharomyces cerevisiae |
| trehalose-6-phosphate synthase | - |
Schizosaccharomyces pombe |
| trehalose-6-phosphate synthase | - |
Candida albicans |
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