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Literature summary for 2.4.1.152 extracted from

  • Yang, X.; Liu, S.; Yan, Q.
    Role of fucosyltransferase IV in epithelial-mesenchymal transition in breast cancer cells (2013), Cell Death Dis., 4, e735.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.1.152

Application

Application Comment Organism
medicine isoform FUT4 is a regulator of epithelial-mesenchymal transition in breast cancer cells and a target for cancer therapy Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P22083
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell
-
 Homo sapiens
-
MCF-10A cell
-
 Homo sapiens
-
MCF-7 cell
-
 Homo sapiens
-
MDA-MB-231 cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
fucosyltransferase IV
-
 Homo sapiens
FUT4
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens breast cancer cell lines display increased expression of isoform FUT4 up

General Information

General Information Comment Organism
physiological function fucosyltransferase IV is implicated in the modulation of cell migration, invasion and cancer metastasis. The enzyme has a role in epithelial-mesenchymal transition through activation of the phosphatidylinositol 3-kinase/Akt and nuclear factor-kappaB signaling systems, which induce the key mediators Snail and MMP-9 and facilitate the acquisition of a mesenchymal phenotype Homo sapiens