Cloned (Comment) | Organism |
---|---|
the largest subfamily UGT2B is encoded by genes clustered on chromosome 4, most isozymes show genetic polymorphisms | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-hydroxyflavone | three-dimensional QSAR-model of UGT1A1 substrate inhibition, binding structure and modelling, overview | Homo sapiens | |
bilirubin | three-dimensional QSAR-model of UGT1A1 substrate inhibition, binding structure and modelling, overview | Homo sapiens | |
morphine | three-dimensional QSAR-model of UGT1A1 substrate inhibition, binding structure and modelling, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | the enzyme is involved in clearance and detoxification of many chemical compounds, overview | ? | - |
? | |
additional information | Homo sapiens | the enzyme is involved in clearance and detoxification of many chemical compounds, overview | ? | - |
? | |
UDP-alpha-D-glucuronate + 3-hydroxyflavone | Homo sapiens | isozyme UGT1A1 | UDP + 3-[(beta-D-glucopyranurnosyl)oxy]-flavone | - |
? | |
UDP-D-glucuronate + acceptor | Rattus norvegicus | - |
UDP + acceptor beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + acceptor | Homo sapiens | - |
UDP + acceptor beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + bilirubin | Homo sapiens | isozyme UGT1A1 | UDP + bilirubin beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + morphine | Homo sapiens | isozyme UGT1A1 | UDP + morphine 3-O-beta-D-glucuronoside | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P22309 | isozyme UGT1A1; 17 isozymes | - |
Rattus norvegicus | - |
several isozymes | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
gastrointestinal tract | - |
Rattus norvegicus | - |
gastrointestinal tract | - |
Homo sapiens | - |
kidney | - |
Rattus norvegicus | - |
kidney | - |
Homo sapiens | - |
liver | expression of most isozymes | Rattus norvegicus | - |
liver | expression of most isozymes | Homo sapiens | - |
lung | - |
Rattus norvegicus | - |
lung | - |
Homo sapiens | - |
olfactory epithelium | - |
Rattus norvegicus | - |
olfactory epithelium | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme is involved in clearance and detoxification of many chemical compounds, overview | Rattus norvegicus | ? | - |
? | |
additional information | the enzyme is involved in clearance and detoxification of many chemical compounds, overview | Homo sapiens | ? | - |
? | |
additional information | prediction of substrates for several isozymes by two dimensional-QSAR modelling, regioselective glucuronidation of isozymes, overview, substrate recognition, and multiple pharmacophore perception, overview | Homo sapiens | ? | - |
? | |
UDP-alpha-D-glucuronate + 3-hydroxyflavone | isozyme UGT1A1 | Homo sapiens | UDP + 3-[(beta-D-glucopyranurnosyl)oxy]-flavone | - |
? | |
UDP-D-glucuronate + acceptor | - |
Rattus norvegicus | UDP + acceptor beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + acceptor | - |
Homo sapiens | UDP + acceptor beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + bilirubin | isozyme UGT1A1 | Homo sapiens | UDP + bilirubin beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + morphine | isozyme UGT1A1 | Homo sapiens | UDP + morphine 3-O-beta-D-glucuronoside | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | prediction of protein-protein interactions between isozymes, in silico modelling | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
More | the UGT superfamily is divided into two families, UGT1 and UGT2, the latter is divided into two subfamilies, UGT2A and UGT2B | Rattus norvegicus |
More | the UGT superfamily is divided into two families, UGT1 and UGT2, the latter is divided into two subfamilies, UGT2A and UGT2B | Homo sapiens |
UDP glucuronosyltransferase | - |
Rattus norvegicus |
UDP glucuronosyltransferase | - |
Homo sapiens |
UGT | - |
Rattus norvegicus |
UGT | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0005 | - |
bilirubin | isozyme UGT1A1 | Homo sapiens | |
0.09 | - |
3-hydroxyflavone | isozyme UGT1A1 | Homo sapiens | |
9 | - |
morphine | isozyme UGT1A1 | Homo sapiens |