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Literature summary for 2.4.1.17 extracted from

  • Nishimura, M.; Koeda, A.; Shimizu, T.; Nakayama, M.; Satoh, T.; Narimatsu, S.; Naito, S.
    Comparison of inducibility of sulfotransferase and UDP-glucuronosyltransferase mRNAs by prototypical microsomal enzyme inducers in primary cultures of human and cynomolgus monkey hepatocytes (2008), Drug Metab. Pharmacokinet., 23, 45-53.
    View publication on PubMed
Search for more literature for 2.4.1.17

Activating Compound

Activating Compound Comment Organism Structure
additional information especially rifampicin, dexamethasone, and also omeprazole induce the expression of isozyme UGT1A1, and to a lesser extent of isozymes UGT1A6 and UGT1A9, overview Macaca fascicularis
additional information rifampicin, dexamethasone, and especially omeprazole induce the expression of isozyme UGT1A1, and to a much lesser extent of isozymes UGT1A6 and UGT1A9, overview Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
DNA and amino acid sequence determination, realtime RT-PCR analysis Macaca fascicularis
realtime RT-PCR analysis Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Homo sapiens
-
-
microsome
-
 Macaca fascicularis
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-D-glucuronate + acceptor Homo sapiens
-
 UDP + acceptor beta-D-glucuronoside
-
 ?
UDP-D-glucuronate + acceptor Macaca fascicularis
-
 UDP + acceptor beta-D-glucuronoside
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 female and male Caucasians
-
Macaca fascicularis Q9TSL7 isozyme UGT1A1; female and male cynomolgus monkeys
-
Macaca fascicularis Q9TSL9 isozyme UGT1A6; female and male cynomolgus monkeys
-
Macaca fascicularis Q9TSM0 isozyme UGT1A9; female and male cynomolgus monkeys
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte primary culture Homo sapiens
-
hepatocyte primary culture Macaca fascicularis
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-D-glucuronate + acceptor
-
 Homo sapiens UDP + acceptor beta-D-glucuronoside
-
 ?
UDP-D-glucuronate + acceptor
-
 Macaca fascicularis UDP + acceptor beta-D-glucuronoside
-
 ?

Synonyms

Synonyms Comment Organism
UDP-glucuronosyltransferase
-
 Homo sapiens
UDP-glucuronosyltransferase
-
 Macaca fascicularis