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Literature summary for 2.4.1.40 extracted from

  • Navaratnam, N.; Findlay, J.B.C.; Keen, J.N.; Watkins, W.M.
    Purification, properties and partial amino acid sequence of the blood-group-A-gene-associated alpha-3-N-acetylgalactosaminyltransferase from human gut mucosal tissue (1990), Biochem. J., 271, 93-98.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.1.40

Inhibitors

Inhibitors Comment Organism Structure
CDP
-
 Homo sapiens
Fluorescein mercuriacetate
-
 Homo sapiens
GDP weak Homo sapiens
N-ethylmaleimide weak Homo sapiens
UDP
-
 Homo sapiens
UMP
-
 Homo sapiens
uridine
-
 Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+ maximal activity with 10 mM Mn2+ Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
40000
-
 x * 40000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens transfers N-acetylgalactosamine from UDP-N-acetylgalactosamine to H-active structures to form A determinants ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 blood group A
-

Purification (Commentary)

Purification (Comment) Organism
blood group A Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
gut mucosa
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
7
-
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information effective acceptor substrates contain a subterminal beta-galactosyl residue substituted at the O-2 position with fucose Homo sapiens ?
-
 ?
additional information transfers N-acetylgalactosamine from UDP-N-acetylgalactosamine to H-active structures to form A determinants Homo sapiens ?
-
 ?
UDP-N-acetyl-D-galactosamine + glycoprotein alpha-L-fucosyl-1,2-D-galactose
-
 Homo sapiens UDP + glycoprotein N-acetyl-alpha-D-galactosaminyl-1,3-[alpha-L-fucosyl-1,2]-D-galactose
-
 ?
UDP-N-acetyl-D-galactosamine + lacto-N-fucopentaose I i.e. Fucalpha(1-2)Galbeta(1-3)GlcNAcbeta(1-3)Galbeta(1-4)Glc Homo sapiens UDP + N-acetyl-alpha-D-galactosaminyl-1,3-[lacto-N-fucopentaose I]
-
 ?

Subunits

Subunits Comment Organism
? x * 40000, SDS-PAGE Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7 7.4
-
 Homo sapiens