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Literature summary for 2.4.1.52 extracted from
- The synthesis of teichoic acids. 3. GLUCOSYLATION OF POLYGLYCEROPHOSPHATE (1964), J. Biol. Chem., 239, 3187-3191.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Mn2+ | inhibitory in presence of optimal Mg2+-concentration | Bacillus subtilis |  |
| additional information | vancomycin, novobionin, crystal violet are no inhibitors | Bacillus subtilis |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.04 | - |
UDPglucose | - |
Bacillus subtilis | |
| 0.1 | 2 | poly(glycerophosphate) | depending on chain length | Bacillus subtilis | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Bacillus subtilis | 16020 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | requirement, as active as Mg2+ | Bacillus subtilis | |
| Mg2+ | requirement | Bacillus subtilis | |
| Mn2+ | requirement, much less effective than Mg2+ and inhibitory in presence of optimal Mg2+ concentration | Bacillus subtilis | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDPglucose + poly(glycerophosphate) | Bacillus subtilis | - |
UDP + alpha-D-glucosyl-poly(glycerol phosphate) | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bacillus subtilis | - |
NCTC 3610 | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial | Bacillus subtilis |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| dTDP-glucose + poly(glycerophosphate) | - |
Bacillus subtilis | dTDP + alpha-D-glucosyl-poly(glycerol phosphate) | - |
? | |
| UDP-glucose + poly(glycerophosphate) | - |
Bacillus subtilis | UDP + alpha-D-glucosyl-poly(glycerol phosphate) | - |
? | |
| UDPglucose + poly(glycerophosphate) | - |
Bacillus subtilis | UDP + alpha-D-glucosyl-poly(glycerol phosphate) | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Bacillus subtilis |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
- |
Bacillus subtilis |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 5.5 | 9.5 | 15% of maximal activity at pH 5.5, 60% of maximal activity at pH 9.5 | Bacillus subtilis |
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