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Literature summary for 2.4.1.68 extracted from

  • Struppe, E.; Staudacher, E.
    Occurrence of GDP-L-fucose:beta-N-acetylglucosamine (Fuc to Asn-linked GlcNAc) alpha1,6-fucosyltransferases in porcine, sheep, bovine, rabbit and chicken tissues (2000), Biochim. Biophys. Acta, 1475, 360-368.
    View publication on PubMed
Search for more literature for 2.4.1.68

Inhibitors

Inhibitors Comment Organism Structure
Ca2+
-
 Ovis aries
Co2+
-
 Ovis aries
Cu2+ complete inhibition Bos taurus
Cu2+ complete inhibition Oryctolagus cuniculus
Cu2+ complete inhibition Ovis aries
Cu2+
-
 Sus scrofa
EDTA slight inhibition Bos taurus
Mg2+ slight inhibition Ovis aries
Mn2+ slight inhibition Ovis aries
Mn2+ slight inhibition Sus scrofa
additional information no effect of Ca2+, Co2+ Bos taurus
additional information no effect of EDTA, Ni2+ Oryctolagus cuniculus
additional information no effect of EDTA, Ba2+ Ovis aries
additional information
-
 Sus scrofa
N-ethylmaleimide slight inhibition Gallus gallus
N-ethylmaleimide slight inhibition Oryctolagus cuniculus
N-ethylmaleimide not affected by Ovis aries
N-ethylmaleimide not affected by Sus scrofa
Ni2+
-
 Bos taurus
Ni2+
-
 Ovis aries
Ni2+
-
 Sus scrofa
Zn2+ strong inhibition Bos taurus
Zn2+ strong inhibition Oryctolagus cuniculus
Zn2+ strong inhibition Ovis aries

Metals/Ions

Metals/Ions Comment Organism Structure
Ba2+ slight activation Bos taurus
Ba2+ activation Oryctolagus cuniculus
Ca2+ activation Bos taurus
Ca2+ activation Oryctolagus cuniculus
Co2+ activation Oryctolagus cuniculus
Mg2+ slight activation Bos taurus
Mg2+ slight activation Oryctolagus cuniculus
Mn2+ activation Bos taurus
Mn2+ activation Oryctolagus cuniculus
additional information no effect of Ca2+, Co2+ Bos taurus
additional information effect of divalent metal ions is tissue-dependent Bos taurus
additional information effect of divalent metal ions is tissue-dependent Oryctolagus cuniculus
additional information effect of divalent metal ions is tissue-dependent Ovis aries
additional information no effect of EDTA, Ba2+ Ovis aries
additional information no effect of EDTA, Ni2+ Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminy]asparagine Gallus gallus i.e. GnGn-peptide GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-6)]-N-acetyl-beta-D-glucosaminyl]asparagine
-
 ?
GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminy]asparagine Sus scrofa i.e. GnGn-peptide GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-6)]-N-acetyl-beta-D-glucosaminyl]asparagine
-
 ?
GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminy]asparagine Bos taurus i.e. GnGn-peptide GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-6)]-N-acetyl-beta-D-glucosaminyl]asparagine
-
 ?
GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminy]asparagine Oryctolagus cuniculus i.e. GnGn-peptide GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-6)]-N-acetyl-beta-D-glucosaminyl]asparagine
-
 ?
GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminy]asparagine Ovis aries i.e. GnGn-peptide GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-6)]-N-acetyl-beta-D-glucosaminyl]asparagine
-
 ?

Organic Solvent Stability

Organic Solvent Comment Organism
acetonitrile 10%, stable Gallus gallus
acetonitrile 10%, stable Sus scrofa
acetonitrile 10%, stable Bos taurus
acetonitrile 10%, stable Oryctolagus cuniculus
acetonitrile 10%, stable Ovis aries
Methanol 10%, stable Gallus gallus
Methanol 10%, stable Sus scrofa
Methanol 10%, stable Bos taurus
Methanol 10%, stable Oryctolagus cuniculus
Methanol 10%, stable Ovis aries

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Gallus gallus
-
-
-
Oryctolagus cuniculus
-
-
-
Ovis aries
-
-
-
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partially from several organs Gallus gallus
partially from several organs Sus scrofa
partially from several organs Bos taurus
partially from several organs Oryctolagus cuniculus
partially from several organs Ovis aries

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Gallus gallus
-
brain
-
 Sus scrofa
-
brain
-
 Bos taurus
-
brain
-
 Oryctolagus cuniculus
-
brain
-
 Ovis aries
-
commercial preparation kidney Bos taurus
-
heart
-
 Gallus gallus
-
heart
-
 Sus scrofa
-
heart
-
 Bos taurus
-
heart
-
 Oryctolagus cuniculus
-
heart
-
 Ovis aries
-
liver
-
 Gallus gallus
-
liver
-
 Sus scrofa
-
liver
-
 Bos taurus
-
liver
-
 Oryctolagus cuniculus
-
liver
-
 Ovis aries
-
lung
-
 Gallus gallus
-
lung
-
 Sus scrofa
-
lung
-
 Bos taurus
-
lung
-
 Oryctolagus cuniculus
-
lung
-
 Ovis aries
-

Storage Stability

Storage Stability Organism
-20°C to 37°C: 24 h, no loss of activity Gallus gallus
-20°C to 37°C: 24 h, no loss of activity Sus scrofa
-20°C to 37°C: 24 h, no loss of activity Bos taurus
-20°C to 37°C: 24 h, no loss of activity Oryctolagus cuniculus
-20°C to 37°C: 24 h, no loss of activity Ovis aries

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl]asparagine i.e. GnGn-peptide Gallus gallus GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-6)]-N-acetyl-beta-D-glucosaminyl]asparagine
-
 ?
GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl]asparagine i.e. GnGn-peptide Sus scrofa GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-6)]-N-acetyl-beta-D-glucosaminyl]asparagine
-
 ?
GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl]asparagine i.e. GnGn-peptide Bos taurus GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-6)]-N-acetyl-beta-D-glucosaminyl]asparagine
-
 ?
GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl]asparagine i.e. GnGn-peptide Oryctolagus cuniculus GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-6)]-N-acetyl-beta-D-glucosaminyl]asparagine
-
 ?
GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl]asparagine i.e. GnGn-peptide Ovis aries GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-6)]-N-acetyl-beta-D-glucosaminyl]asparagine
-
 ?
GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminy]asparagine i.e. GnGn-peptide Gallus gallus GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-6)]-N-acetyl-beta-D-glucosaminyl]asparagine
-
 ?
GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminy]asparagine i.e. GnGn-peptide Sus scrofa GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-6)]-N-acetyl-beta-D-glucosaminyl]asparagine
-
 ?
GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminy]asparagine i.e. GnGn-peptide Bos taurus GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-6)]-N-acetyl-beta-D-glucosaminyl]asparagine
-
 ?
GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminy]asparagine i.e. GnGn-peptide Oryctolagus cuniculus GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-6)]-N-acetyl-beta-D-glucosaminyl]asparagine
-
 ?
GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminy]asparagine i.e. GnGn-peptide Ovis aries GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-6)]-N-acetyl-beta-D-glucosaminyl]asparagine
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
additional information
-
 overview: tissue specific pH-optima Gallus gallus
additional information
-
 overview: tissue specific pH-optima Sus scrofa
additional information
-
 overview: tissue specific pH-optima Bos taurus
additional information
-
 overview: tissue specific pH-optima Oryctolagus cuniculus
additional information
-
 overview: tissue specific pH-optima Ovis aries

pH Stability

pH Stability pH Stability Maximum Comment Organism
4 9
-
 Gallus gallus
4 9
-
 Sus scrofa
4 9
-
 Bos taurus
4 9
-
 Oryctolagus cuniculus
4 9
-
 Ovis aries