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Literature summary for 2.4.1.80 extracted from

  • Ichikawa, S.; Sakiyama, H.; Suzuki, G.; Hidari, K.I.P.J.; Hirabayashi, Y.
    Expression cloning of a cDNA for human ceramide glucosyltransferase that catalyzes the first glycosylation step of glycosphingolipid synthesis (1996), Proc. Natl. Acad. Sci. USA, 93, 4638-4643.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
cloning and transient expression in GM-95 cell line, mutant cell line containing no enzyme activity, derived from melanoma mutant cell line B16, DNA sequence determination and analysis Homo sapiens
functional expression in Escherichia coli BL21(DE3) Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
additional information
-
amino acid sequence Homo sapiens
448530
-
x * 448530, amino acid sequence determination Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-glucose + N-acylsphingosine Homo sapiens first step in synthesis of gangliosides UDP + D-glucosyl-N-acylsphingosine i.e. glucosylceramide ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q16739
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain mRNA Homo sapiens
-
heart mRNA Homo sapiens
-
kidney mRNA Homo sapiens
-
liver mRNA Homo sapiens
-
lung mRNA Homo sapiens
-
pancreas mRNA Homo sapiens
-
placenta mRNA Homo sapiens
-
skeletal muscle mRNA Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-glucose + N-acylsphingosine i.e. ceramide Homo sapiens UDP + D-glucosyl-N-acylsphingosine i.e. glucosylceramide ?
UDP-glucose + N-acylsphingosine first step in synthesis of gangliosides Homo sapiens UDP + D-glucosyl-N-acylsphingosine i.e. glucosylceramide ?

Subunits

Subunits Comment Organism
? x * 448530, amino acid sequence determination Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Homo sapiens