Application | Comment | Organism |
---|---|---|
medicine | - |
Homo sapiens |
medicine | enzyme inhibition is a possible target for chemotherapeutic agents for a number of diseases, including cancer | Rattus norvegicus |
Cloned (Comment) | Organism |
---|---|
cloning from rat brain genetic library and expression in Escherichia coli BL21(DE3) | Rattus norvegicus |
functional expression in Escherichia coli BL21(DE3) | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
EDTA | no inhibition | Rattus norvegicus | |
additional information | - |
Gallus gallus | |
additional information | - |
Homo sapiens | |
additional information | no inhibition by DTT | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
Golgi membrane | integral membrane protein | Sus scrofa | 139 | - |
Golgi membrane | orientation to the cytosolic side | Rattus norvegicus | 139 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | stimulates | Mus musculus | |
Ca2+ | stimulates | Homo sapiens | |
Ca2+ | stimulates | Rattus norvegicus | |
Mg2+ | stimulates | Mus musculus | |
Mg2+ | stimulates | Homo sapiens | |
Mg2+ | stimulates | Rattus norvegicus | |
Mg2+ | stimulates | Sus scrofa | |
Mn2+ | stimulates | Mus musculus | |
Mn2+ | stimulates | Homo sapiens | |
Mn2+ | stimulates | Rattus norvegicus | |
Mn2+ | stimulates | Sus scrofa |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Mus musculus |
additional information | - |
- |
Homo sapiens |
additional information | - |
- |
Rattus norvegicus |
additional information | - |
enzyme forms dimeric or oligomeric complexes with another protein in the Golgi membrane vivo, topology | Homo sapiens |
additional information | - |
enzyme forms dimeric or oligomeric complexes with another protein in the Golgi membrane vivo, topology | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-glucose + N-acylsphingosine | Gallus gallus | - |
UDP + D-glucosyl-N-acylsphingosine | - |
? | |
UDP-glucose + N-acylsphingosine | Homo sapiens | - |
UDP + D-glucosyl-N-acylsphingosine | - |
? | |
UDP-glucose + N-acylsphingosine | Sus scrofa | - |
UDP + D-glucosyl-N-acylsphingosine | - |
? | |
UDP-glucose + N-acylsphingosine | Mus musculus | - |
UDP + D-glucosyl-N-acylsphingosine | i.e. glucosylceramide | ? | |
UDP-glucose + N-acylsphingosine | Rattus norvegicus | - |
UDP + D-glucosyl-N-acylsphingosine | i.e. glucosylceramide | ? | |
UDP-glucose + N-acylsphingosine | Homo sapiens | - |
UDP + D-glucosyl-N-acylsphingosine | i.e. glucosylceramide | ? | |
UDP-glucose + N-acylsphingosine | Rattus norvegicus Sprague-Dawley | - |
UDP + D-glucosyl-N-acylsphingosine | i.e. glucosylceramide | ? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Gallus gallus | - |
- |
- |
Homo sapiens | - |
- |
- |
Homo sapiens | Q16739 | - |
- |
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
Sprague-Dawley | - |
Rattus norvegicus | Q9R0E0 | - |
- |
Rattus norvegicus Sprague-Dawley | - |
Sprague-Dawley | - |
Sus scrofa | - |
- |
- |
Purification (Comment) | Organism |
---|---|
partial from Golgi membranes | Rattus norvegicus |
solubilization method | Rattus norvegicus |
solubilization method | Sus scrofa |
Renatured (Comment) | Organism |
---|---|
reconstitution of solubilized enzyme in detergent-free lipid vesicles | Rattus norvegicus |
reconstitution of solubilized enzyme in detergent-free lipid vesicles | Sus scrofa |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
keratinocyte | - |
Homo sapiens | - |
liver | - |
Mus musculus | - |
liver | - |
Homo sapiens | - |
liver | low level | Rattus norvegicus | - |
lung | - |
Rattus norvegicus | - |
lung | - |
Homo sapiens | - |
spleen | - |
Rattus norvegicus | - |
testis | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Gallus gallus |
additional information | - |
- |
Mus musculus |
additional information | - |
- |
Homo sapiens |
additional information | - |
- |
Sus scrofa |
additional information | - |
fluorescence assay method | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-glucose + N-acylsphingosine | - |
Gallus gallus | UDP + D-glucosyl-N-acylsphingosine | - |
? | |
UDP-glucose + N-acylsphingosine | - |
Homo sapiens | UDP + D-glucosyl-N-acylsphingosine | - |
? | |
UDP-glucose + N-acylsphingosine | - |
Sus scrofa | UDP + D-glucosyl-N-acylsphingosine | - |
? | |
UDP-glucose + N-acylsphingosine | - |
Mus musculus | UDP + D-glucosyl-N-acylsphingosine | i.e. glucosylceramide | ? | |
UDP-glucose + N-acylsphingosine | - |
Rattus norvegicus | UDP + D-glucosyl-N-acylsphingosine | i.e. glucosylceramide | ? | |
UDP-glucose + N-acylsphingosine | - |
Homo sapiens | UDP + D-glucosyl-N-acylsphingosine | i.e. glucosylceramide | ? | |
UDP-glucose + N-acylsphingosine | i.e. ceramide | Gallus gallus | UDP + D-glucosyl-N-acylsphingosine | i.e. glucosylceramide | ? | |
UDP-glucose + N-acylsphingosine | i.e. ceramide | Mus musculus | UDP + D-glucosyl-N-acylsphingosine | i.e. glucosylceramide | ? | |
UDP-glucose + N-acylsphingosine | i.e. ceramide | Homo sapiens | UDP + D-glucosyl-N-acylsphingosine | i.e. glucosylceramide | ? | |
UDP-glucose + N-acylsphingosine | i.e. ceramide | Rattus norvegicus | UDP + D-glucosyl-N-acylsphingosine | i.e. glucosylceramide | ? | |
UDP-glucose + N-acylsphingosine | i.e. ceramide | Sus scrofa | UDP + D-glucosyl-N-acylsphingosine | i.e. glucosylceramide | ? | |
UDP-glucose + N-acylsphingosine | - |
Rattus norvegicus Sprague-Dawley | UDP + D-glucosyl-N-acylsphingosine | i.e. glucosylceramide | ? | |
UDP-glucose + N-acylsphingosine | i.e. ceramide | Rattus norvegicus Sprague-Dawley | UDP + D-glucosyl-N-acylsphingosine | i.e. glucosylceramide | ? | |
UDP-glucose + N-[7-(4-nitrobenzo-2-oxa-1,3-diazole)]-6-aminocaproyl-D-erythro-sphingosine | synthetic fluorescent ceramide substrate analogue for fluorescence enzyme assay | Rattus norvegicus | UDP + D-glucosyl-N-[7-(4-nitrobenzo-2-oxa-1,3-diazole)]-6-aminocaproyl-D-erythro-sphingosine | - |
? | |
UDP-glucose + N-[7-(4-nitrobenzo-2-oxa-1,3-diazole)]-6-aminocaproyl-D-erythro-sphingosine | synthetic fluorescent ceramide substrate analogue for fluorescence enzyme assay | Rattus norvegicus Sprague-Dawley | UDP + D-glucosyl-N-[7-(4-nitrobenzo-2-oxa-1,3-diazole)]-6-aminocaproyl-D-erythro-sphingosine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GCS | - |
Mus musculus |
GCS | - |
Homo sapiens |
GCS | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Mus musculus |
37 | - |
assay at | Rattus norvegicus |
37 | - |
assay at | Sus scrofa |
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
- |
Mus musculus |
7.4 | - |
- |
Homo sapiens |
7.4 | - |
assay at | Rattus norvegicus |