Cloned (Comment) | Organism |
---|---|
expression in Saccharomyces cerevisiae | Cryptococcus neoformans |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-glucose + N-acylsphingosine | Cryptococcus neoformans | GCS is a key regulator of pathogenicity of Cryptococcus neoformans by ensuring cell cycle progression and growth of fungal cells in environments characterized by neutral/alkaline pH and physiological concentrations of CO2. Since these environments are characteristically found in the lung alveolar spaces, GCS regulates survival of Cryptococcus neoformans upon inhalation through the respiratory tract, with important implications for the dissemination of fungal cells to the brain and the development of meningo-encephalitis | UDP + D-glucosyl-N-acylsphingosine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cryptococcus neoformans | Q58FH5 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-glucose + N-acylsphingosine | GCS is a key regulator of pathogenicity of Cryptococcus neoformans by ensuring cell cycle progression and growth of fungal cells in environments characterized by neutral/alkaline pH and physiological concentrations of CO2. Since these environments are characteristically found in the lung alveolar spaces, GCS regulates survival of Cryptococcus neoformans upon inhalation through the respiratory tract, with important implications for the dissemination of fungal cells to the brain and the development of meningo-encephalitis | Cryptococcus neoformans | UDP + D-glucosyl-N-acylsphingosine | - |
? | |
UDP-glucose + N-acylsphingosine | Cryptococcus neoformans Gcs1 expressed in Saccharomyces cerevisiae is unable to recognize 7-nitro-2-1,3-benzoxadiazol-4-yl-ceramide analogs as substrates | Cryptococcus neoformans | UDP + D-glucosyl-N-acylsphingosine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GCS1 | - |
Cryptococcus neoformans |