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Literature summary for 2.4.2.1 extracted from
- Expression of human malaria parasite purine nucleoside phosphorylase in host enzyme-deficient erythrocyte culture. Enzyme characterization and identification of novel inhibitors (1986), J. Biol. Chem., 261, 11667-11673.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | - |
Homo sapiens |
| medicine | the enzyme inhibitors 8-amino-5'-deoxy-5'-chloroguanosine and 8-amino-9-benzylguanine may have some antimalarial potential by limiting hypoxanthine production in the parasite-infected erythrocyte | Plasmodium falciparum |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 5'-chloro-5'-deoxy-8-aminoguanosine | - |
Homo sapiens |  |
| 5'-chloro-5'-deoxy-8-aminoguanosine | - |
Plasmodium falciparum | |
| 8-amino-5'-deoxy-5'-chloroguanosine | - |
Homo sapiens | |
| 8-amino-5'-deoxy-5'-chloroguanosine | - |
Plasmodium falciparum | |
| 8-Amino-9-benzylguanine | - |
Homo sapiens | |
| 8-Amino-9-benzylguanine | - |
Plasmodium falciparum | |
| 8-aminoguanosine | - |
Homo sapiens | |
| 8-aminoguanosine | - |
Plasmodium falciparum | |
| formycin B | - |
Homo sapiens | |
| formycin B | - |
Plasmodium falciparum | |
| additional information | the enzyme inhibitors 8-amino-5'-deoxy-5'-chloroguanosine and 8-amino-9-benzylguanine may have some antimalarial potential by limiting hypoxanthine production in the parasite-infected erythrocyte | Plasmodium falciparum |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.01 | - |
Inosine | - |
Plasmodium falciparum | |
| 0.01 | - |
guanosine | - |
Plasmodium falciparum | |
| 0.035 | - |
guanosine | - |
Homo sapiens | |
| 0.038 | - |
deoxyguanosine | - |
Homo sapiens | |
| 0.041 | - |
Inosine | - |
Homo sapiens | |
| 0.057 | - |
deoxyguanosine | - |
Plasmodium falciparum | |
| 0.43 | - |
phosphate | - |
Homo sapiens | |
| 0.68 | - |
phosphate | - |
Plasmodium falciparum | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 147000 | - |
sucrose density gradient centrifugation | Plasmodium falciparum |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Plasmodium falciparum | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| deoxyguanosine + phosphate | - |
Homo sapiens | guanine + alpha-D-deoxyribose 1-phosphate | - |
? | |
| deoxyguanosine + phosphate | - |
Plasmodium falciparum | guanine + alpha-D-deoxyribose 1-phosphate | - |
? | |
| guanosine + phosphate | - |
Homo sapiens | guanine + alpha-D-ribose 1-phosphate | - |
? | |
| guanosine + phosphate | - |
Plasmodium falciparum | guanine + alpha-D-ribose 1-phosphate | - |
? | |
| inosine + phosphate | - |
Homo sapiens | hypoxanthine + alpha-D-ribose 1-phosphate | - |
? | |
| inosine + phosphate | - |
Plasmodium falciparum | hypoxanthine + alpha-D-ribose 1-phosphate | - |
? | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0002 | - |
8-Amino-9-benzylguanine | - |
Homo sapiens | |
| 0.0004 | - |
5'-chloro-5'-deoxy-8-aminoguanosine | - |
Homo sapiens | |
| 0.0011 | - |
formycin B | - |
Plasmodium falciparum | |
| 0.007 | - |
8-aminoguanosine | - |
Homo sapiens | |
| 0.008 | - |
8-Amino-9-benzylguanine | - |
Plasmodium falciparum | |
| 0.012 | - |
5'-chloro-5'-deoxy-8-aminoguanosine | - |
Plasmodium falciparum | |
| 0.013 | - |
8-aminoguanosine | - |
Plasmodium falciparum | |
| 0.13 | - |
formycin B | - |
Homo sapiens | |
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