Crystallization (Comment) | Organism |
---|---|
in complex with inhibitor 6-amino-5-bromopyrimidine-2,4(1H,3H)-dione, to 1.9 A resolution | Schistosoma mansoni |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-[4-(2,4-dimethylphenyl)-1,3-thiazol-2-yl]guanidine | 0.1 mM , 79.5% inhibition | Schistosoma mansoni | |
1-[4-(4-methylphenyl)-1,3-thiazol-2-yl]guanidine | 0.1 mM , 70.6% inhibition | Schistosoma mansoni | |
6-amino-5-bromopyrimidine-2,4(1H,3H)-dione | formation of eight hydrogen bonds with key residues in the active site E203, N245 and T244 | Schistosoma mansoni |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Schistosoma mansoni | Q9BMI9 | - |
- |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0013 | - |
pH 7.0 | Schistosoma mansoni | 6-amino-5-bromopyrimidine-2,4(1H,3H)-dione |