General Stability | Organism |
---|---|
immobilization does not affect the catalytic activity and efficiency of the enzyme | Schistosoma mansoni |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-amino-7-[(3-hydroxyphenyl)methyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one | 1.82% inhibition at 0.2 mM | Schistosoma mansoni | |
2-amino-7-[(pyridin-3-yl)methyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one | 35.2% inhibition at 0.2 mM | Schistosoma mansoni | |
2-amino-7-[([1,1'-biphenyl]-4-yl)methyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one | 1.52% inhibition at 0.2 mM | Schistosoma mansoni | |
3-(4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)-3-(pyridin-3-yl)propanenitrile | 72.7% inhibition at 0.2 mM | Schistosoma mansoni | |
7-benzyl-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one | 11% inhibition at 0.2 mM | Schistosoma mansoni | |
phosphate | high phosphate concentrations negatively affect the affinity of the enzyme for inosine | Schistosoma mansoni |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.11 | - |
Inosine | free enzyme, at pH 7.4, temperature not specified in the publication | Schistosoma mansoni | |
0.164 | - |
Inosine | immobilized enzyme, at pH 7.4, temperature not specified in the publication | Schistosoma mansoni |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Schistosoma mansoni | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
inosine + phosphate | - |
Schistosoma mansoni | hypoxanthine + alpha-D-ribose 1-phosphate | - |
r |
Synonyms | Comment | Organism |
---|---|---|
PNP | - |
Schistosoma mansoni |
purine nucleoside phosphorylase | - |
Schistosoma mansoni |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0075 | - |
pH and temperature not specified in the publication | Schistosoma mansoni | 3-(4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)-3-(pyridin-3-yl)propanenitrile |