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Literature summary for 2.4.2.1 extracted from

  • Furihata, T.; Kishida, S.; Sugiura, H.; Kamiichi, A.; Iikura, M.; Chiba, K.
    Functional analysis of purine nucleoside phosphorylase as a key enzyme in ribavirin metabolism (2014), Drug Metab. Pharmacokinet., 29, 211-214.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
G51S the mutant possesses wild type phosphorylase activity levels toward inosine and ribavirin Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
ganciclovir
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Homo sapiens 5829
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
30000
-
x * 30000, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
His-Talon column chromatography Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-
small intestine high expression Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
inosine + phosphate
-
Homo sapiens hypoxanthine + alpha-D-ribose 1-phosphate
-
r
ribavirin + phosphate
-
Homo sapiens 1,2,4-triazole-3-carboxamide + alpha-D-ribose 1-phosphate
-
?

Subunits

Subunits Comment Organism
? x * 30000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
PNP
-
Homo sapiens
purine nucleoside phosphorylase
-
Homo sapiens

General Information

General Information Comment Organism
metabolism key enzyme in ribavirin metabolism of the human small intestine Homo sapiens