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Literature summary for 2.4.2.12 extracted from

  • Oita, R.C.; Camp, S.M.; Ma, W.; Ceco, E.; Harbeck, M.; Singleton, P.; Messana, J.; Sun, X.; Wang, T.; Garcia, J.G.N.
    Novel mechanism for nicotinamide phosphoribosyltransferase inhibition of TNF-alpha-mediated apoptosis in human lung endothelial cells (2018), Am. J. Respir. Cell Mol. Biol., 59, 36-44 .
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
FK866 selective inhibitor Homo sapiens
GMX1778
-
 Homo sapiens
N-([4-(3,5-difluorobenzene-1-sulfonyl)phenyl]methyl)imidazo[1,2-a]pyridine-6-carboxamide GNE-617 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
nicotinamide D-ribonucleotide + diphosphate Homo sapiens
-
 nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P43490
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lung endothelial cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
nicotinamide D-ribonucleotide + diphosphate
-
 Homo sapiens nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
-
 ?

Subunits

Subunits Comment Organism
? x * 55000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
Nampt
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction reduced enzyme expression increases endothelial cell susceptibility to tumor necrosis factor-alpha-induced apoptosis as reflected by PARP-1 cleavage and caspase-3 activation Homo sapiens
physiological function enzyme overexpression serves to reduce degrees of tumor necrosis factor-alpha-induced endothelial cell apoptosis Homo sapiens