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Literature summary for 2.4.2.12 extracted from

  • Svoboda, P.; Krizova, E.; Sestakova, S.; Vapenkova, K.; Knejzlik, Z.; Rimpelova, S.; Rayova, D.; Volfova, N.; Krizova, I.; Rumlova, M.; Sykora, D.; Kizek, R.; Haluzik, M.; Zidek, V.; Zidkova, J.; Skop, V.
    Nuclear transport of nicotinamide phosphoribosyltransferase is cell cycle-dependent in mammalian cells, and its inhibition slows cell growth (2019), J. Biol. Chem., 294, 8676-8689 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.2.12

Application

Application Comment Organism
medicine specific inhibition of enzyme transport into the nucleus might be a potential avenue for managing cancer Mus musculus
medicine specific inhibition of enzyme transport into the nucleus might be a potential avenue for managing cancer Homo sapiens

Protein Variants

Protein Variants Comment Organism
D219A inactive Mus musculus
D219A inactive Homo sapiens
D313A inactive Mus musculus
D313A inactive Homo sapiens
R311A inactive Mus musculus
R311A inactive Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
FK866
-
 Homo sapiens
FK866
-
 Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Mus musculus 5737
-
cytoplasm
-
 Homo sapiens 5737
-
nucleus
-
 Homo sapiens 5634
-
nucleus the enzyme is localized in the nucleus in non-dividing adipocytes and is present in both the cytoplasm and the nucleus in dividing cells Mus musculus 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
nicotinamide D-ribonucleotide + diphosphate Mus musculus
-
 nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
-
 ?
nicotinamide D-ribonucleotide + diphosphate Homo sapiens
-
 nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P43490
-
-
Mus musculus Q99KQ4
-
-

Source Tissue

Source Tissue Comment Organism Textmining
3T3-L1 cell
-
 Mus musculus
-
Hep-G2 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
nicotinamide D-ribonucleotide + diphosphate
-
 Mus musculus nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
-
 ?
nicotinamide D-ribonucleotide + diphosphate
-
 Homo sapiens nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
-
 ?

Subunits

Subunits Comment Organism
? x * 55000, SDS-PAGE Mus musculus
? x * 55000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
Nampt
-
 Mus musculus
Nampt
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism the enzyme catalyzes the rate-limiting step in NAD synthesis Mus musculus
metabolism the enzyme catalyzes the rate-limiting step in NAD synthesis Homo sapiens