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Literature summary for 2.4.2.17 extracted from

  • Alphey, M.; Fisher, G.; Ge, Y.; Gould, E.; Machado, T.; Liu, H.; Florence, G.; Naismith, J.; Da Silva, R.
    Catalytic and anticatalytic snapshots of a short-form ATP phosphoribosyltransferase (2018), ACS Catal., 8, 5601-5610 .
No PubMed abstract available

Crystallization (Commentary)

Crystallization (Comment) Organism
holoenzyme and catalytic subunit HisGS in complexes with substrates (5-phospho-alpha-D-ribose 1-diphosphate, 5-phospho-alpha-D-ribose 1-diphosphate-ATP, 5-phospho-alpha-D-ribose 1-diphosphate-ADP), product (N1-(5-phospho-beta-D-ribosyl)-ATP) and inhibitor (AMP), hanging drop vapor diffusion method, using 10% (w/v) polyethylene glycol 3350, 0.1 M bicine pH 8.5, 50 mM MgCl2, 0.1 M KBr, and 4% (v/v) 1,6-hexanediol Psychrobacter arcticus

Inhibitors

Inhibitors Comment Organism Structure
AMP
-
Psychrobacter arcticus
L-histidine
-
Psychrobacter arcticus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ dependent on Psychrobacter arcticus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 5-phospho-alpha-D-ribose 1-diphosphate Psychrobacter arcticus
-
N1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
-
r
ATP + 5-phospho-alpha-D-ribose 1-diphosphate Psychrobacter arcticus DSM 17307
-
N1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
-
r

Organism

Organism UniProt Comment Textmining
Psychrobacter arcticus Q4FQF7
-
-
Psychrobacter arcticus DSM 17307 Q4FQF7
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
-
Psychrobacter arcticus N1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
-
r
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
-
Psychrobacter arcticus DSM 17307 N1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate
-
r

Subunits

Subunits Comment Organism
heterooctamer the enzyme consist of four catalytic subunits (HisGS) and four regulatory subunits (HisZ) Psychrobacter arcticus

Synonyms

Synonyms Comment Organism
adenosine 5'-triphosphate phosphoribosyltransferase
-
Psychrobacter arcticus
ATPPRT
-
Psychrobacter arcticus
HisG
-
Psychrobacter arcticus