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Literature summary for 2.4.2.18 extracted from

  • Castell, A.; Short, F.L.; Evans, G.L.; Cookson, T.V.; Bulloch, E.M.; Joseph, D.D.; Lee, C.E.; Parker, E.J.; Baker, E.N.; Lott, J.S.
    The substrate capture mechanism of Mycobacterium tuberculosis anthranilate phosphoribosyltransferase provides a mode for inhibition (2013), Biochemistry, 52, 1776-1787.
    View publication on PubMed
Search for more literature for 2.4.2.18

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Mycobacterium tuberculosis

Protein Variants

Protein Variants Comment Organism
D282A inactive Mycobacterium tuberculosis
G308L inactive Mycobacterium tuberculosis
H307A inactive Mycobacterium tuberculosis
N309A inactive Mycobacterium tuberculosis
T279A inactive Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate Mycobacterium tuberculosis
-
 N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis P9WFX5
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni-NTA column chromatography Mycobacterium tuberculosis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-amino-2-pentenoate + 5-phospho-alpha-D-ribose 1-diphosphate good substrate Mycobacterium tuberculosis N-(5-phospho-D-ribosyl)-2-amino-2-pentenoate + diphosphate
-
 ?
2-aminoacrylate + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Mycobacterium tuberculosis N-(5-phospho-D-ribosyl)-2-aminoacrylate + diphosphate
-
 ?
2-aminocrotonate + 5-phospho-alpha-D-ribose 1-diphosphate good substrate Mycobacterium tuberculosis N-(5-phospho-D-ribosyl)-2-aminocrotonate + diphosphate
-
 ?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Mycobacterium tuberculosis N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
 ?
additional information no activity with 2-aminobutyrate Mycobacterium tuberculosis ?
-
 ?

Synonyms

Synonyms Comment Organism
anthranilate phosphoribosyl transferase
-
 Mycobacterium tuberculosis
TrpD
-
 Mycobacterium tuberculosis