Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli | Mycobacterium tuberculosis |
Protein Variants | Comment | Organism |
---|---|---|
D282A | inactive | Mycobacterium tuberculosis |
G308L | inactive | Mycobacterium tuberculosis |
H307A | inactive | Mycobacterium tuberculosis |
N309A | inactive | Mycobacterium tuberculosis |
T279A | inactive | Mycobacterium tuberculosis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate | Mycobacterium tuberculosis | - |
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | P9WFX5 | - |
- |
Purification (Comment) | Organism |
---|---|
Ni-NTA column chromatography | Mycobacterium tuberculosis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-amino-2-pentenoate + 5-phospho-alpha-D-ribose 1-diphosphate | good substrate | Mycobacterium tuberculosis | N-(5-phospho-D-ribosyl)-2-amino-2-pentenoate + diphosphate | - |
? | |
2-aminoacrylate + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Mycobacterium tuberculosis | N-(5-phospho-D-ribosyl)-2-aminoacrylate + diphosphate | - |
? | |
2-aminocrotonate + 5-phospho-alpha-D-ribose 1-diphosphate | good substrate | Mycobacterium tuberculosis | N-(5-phospho-D-ribosyl)-2-aminocrotonate + diphosphate | - |
? | |
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Mycobacterium tuberculosis | N-(5-phospho-D-ribosyl)-anthranilate + diphosphate | - |
? | |
additional information | no activity with 2-aminobutyrate | Mycobacterium tuberculosis | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
anthranilate phosphoribosyl transferase | - |
Mycobacterium tuberculosis |
TrpD | - |
Mycobacterium tuberculosis |