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Literature summary for 2.4.2.21 extracted from
- alpha-5,6-Dimethylbenzimidazole adenine dinucleotide (alpha-DAD), a putative new intermediate of coenzyme B12 biosynthesis in Salmonella typhimurium (2003), Microbiology, 149, 983-990.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.51 | - |
NMN | pH 7.0, 37°C | Salmonella enterica subsp. enterica serovar Typhimurium |  |
| 9 | - |
NAD+ | pH 7.0, 37°C | Salmonella enterica subsp. enterica serovar Typhimurium | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| NAD+ + 5,6-dimethylbenzimidazole | Salmonella enterica subsp. enterica serovar Typhimurium | step in the biosynthesis of coenzyme B12, nuceotide loop assembly NLA pathway overview | nicotinamide + alpha-5,6-dimethylbenzimidazole adenine dinucleotide | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Salmonella enterica subsp. enterica serovar Typhimurium | - |
gene cobT | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Salmonella enterica subsp. enterica serovar Typhimurium |
| 0.0021 | - |
cell extract, substrate NMN | Salmonella enterica subsp. enterica serovar Typhimurium |
| 0.0025 | - |
cell extract, substrate NAD+ | Salmonella enterica subsp. enterica serovar Typhimurium |
| 0.035 | - |
cell extract, substrate beta-nicotinate D-riboadenosine | Salmonella enterica subsp. enterica serovar Typhimurium |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| beta-nicotinate D-ribonucleotide + 5,6-dimethylbenzimidazole | - |
Salmonella enterica subsp. enterica serovar Typhimurium | nicotinate + N1-(5-phospho-alpha-D-ribosyl)-5,6-dimethylbenzimidazole | - |
? | |
| additional information | substrate specificity | Salmonella enterica subsp. enterica serovar Typhimurium | ? | - |
? | |
| NAD+ + 5,6-dimethylbenzimidazole | - |
Salmonella enterica subsp. enterica serovar Typhimurium | nicotinamide + alpha-5,6-dimethylbenzimidazole adenine dinucleotide | alpha-5,6-dimethylbenzimidazole adenine dinucleotide product identification by mass spectrometry | ? | |
| NAD+ + 5,6-dimethylbenzimidazole | step in the biosynthesis of coenzyme B12, nuceotide loop assembly NLA pathway overview | Salmonella enterica subsp. enterica serovar Typhimurium | nicotinamide + alpha-5,6-dimethylbenzimidazole adenine dinucleotide | - |
? | |
| NMN + 5,6-dimethylbenzimidazole | - |
Salmonella enterica subsp. enterica serovar Typhimurium | nicotinamide + ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CobT | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Salmonella enterica subsp. enterica serovar Typhimurium |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.62 | - |
NAD+ | pH 7.0, 37°C | Salmonella enterica subsp. enterica serovar Typhimurium | |
| 149 | - |
NMN | pH 7.0, 37°C | Salmonella enterica subsp. enterica serovar Typhimurium | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| additional information | - |
assay at pH 7.0 or pH 10.0 | Salmonella enterica subsp. enterica serovar Typhimurium |
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