Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.4.2.30 extracted from

  • Banasik, M.; Komura, H.; Shimoyama, M.; Ueda, K.
    Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferase (1992), J. Biol. Chem., 267, 1569-1575.
    View publication on PubMed
Search for more literature for 2.4.2.30

Activating Compound

Activating Compound Comment Organism Structure
4-[[[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl](pyridin-2-ylsulfonyl)amino]methyl]-N,N-dimethylpiperidine-1-carboxamide activates in presence of Mg2+, inhibits in absence of Mg2+ Bos taurus
harmaline hydrochloride activates more strongly in absence of Mg2+ than in presence of Mg2+ Bos taurus
Phthalic acid activates more strongly in absence of Mg2+ than in presence of Mg2+ Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
1(2H)-phthalazinone IC50: 0.012 mM Bos taurus
1,2-benzopyrone IC50: 2.8 mM Bos taurus
1,3-benzodiazine IC50: 2.0 mM Bos taurus
1,3-dihydroxynaphthalene IC50: 1.3 mM Bos taurus
1,4-benzoquinone IC50: 0.4 mM Bos taurus
1,4-naphthalenedione IC50: 0.25 mM Bos taurus
1,5-dihydroxyisoquinoline IC50: 0.00039 mM Bos taurus
1,8-naphthalimide IC50: 0.0014 mM Bos taurus
1-hydroxy-2-methyl-4-aminonaphthalene IC50: 1.3 mM Bos taurus
1-hydroxyisoquinoline IC50: 0.007 mM Bos taurus
1-Indanone IC50: 0.81 mM Bos taurus
1-methylnicotinamide chloride IC50: 3.8 mM Bos taurus
2,3-benzodiazine IC50: 0.15 mM Bos taurus
2,3-dichloro-1,4-naphthoquinone IC50: 0.26 mM Bos taurus
2,3-dihydro-1,4-phthalazinedione IC50: 0.03 mM Bos taurus
2,4(1H,3H)-quinazolinedione IC50: 0.0081 mM Bos taurus
2,6-difluorobenzamide IC50: 0.18 mM Bos taurus
2-acetamidobenzamide IC50: 1.0 mM Bos taurus
2-amino-3-chloro-1,4-naphthoquinone IC50: 0.82 mM Bos taurus
2-Aminobenzamide IC50: 0.65 mM Bos taurus
2-bromobenzamide IC50: 2.9 mM Bos taurus
2-chlorobenzamide IC50: 1.0 mM Bos taurus
2-fluorobenzamide IC50: 0.12 mM Bos taurus
2-Hydroxy-1,4-naphthoquinone IC50: 0.33 mM Bos taurus
2-hydroxybenzamide IC50: 0.82 mM Bos taurus
2-mercapto-4(3H)-quinazolinone IC50: 0.044 mM Bos taurus
2-Methoxybenzamide IC50: 0.2 mM Bos taurus
2-methyl-1,4-benzopyrone IC50: 0.045 mM Bos taurus
2-methyl-1,4-naphthoquinone IC50: 0.42 mM Bos taurus
2-methyl-3-phytyl-1,4-naphthoquinone IC50: 0.52 mM Bos taurus
2-methyl-4(3H)-quinazolinone IC50: 0.056 mM Bos taurus
2-methylbenzamide IC50: 1.5 mM Bos taurus
2-methylchromone IC50: 0.045 mM Bos taurus
2-nitro-6(5H)-phenanthridione IC50: 0.00035 mM Bos taurus
2-phenylchromone IC50: 0.022 mM Bos taurus
2-trichloromethyl-4(3H)-quinazolinone IC50: 2.2 mM Bos taurus
2H-benz[c]isoquinolin-1-one IC50: 0.0003 mM Bos taurus
2H-benz[de]isoquinoline-1,3-dione IC50: 0.0014 mM Bos taurus
3,4-dihydro-1(2H)-naphthalenone IC50: 0.31 mM Bos taurus
3,5-dibromosalicylamide IC50: 0.56 mM Bos taurus
3,5-dimethoxybenzamide IC50: 1.2 mM Bos taurus
3,5-dinitrobenzamide IC50: 2.5 mM Bos taurus
3-(N,N-dimethylamino)benzamide IC50: 0.12 mM Bos taurus
3-Acetamidobenzamide IC50: 0.012 mM Bos taurus
3-acetamidosalicylamide IC50: 2.0 mM Bos taurus
3-aminobenzamide IC50: 0.33 mM Bos taurus
3-Aminophthalhydrazide IC50: 0.023 mM Bos taurus
3-bromobenzamide IC50: 0.055 mM Bos taurus
3-Chlorobenzamide IC50: 0.22 mM Bos taurus
3-Fluorobenzamide IC50: 0.2 mM Bos taurus
3-Hydroxybenzamide IC50: 0.0091 mM Bos taurus
3-Methoxybenzamide IC50: 0.017 mM Bos taurus
3-Methylbenzamide IC50: 0.19 mM Bos taurus
3-nitrobenzamide IC50: 0.16 mM Bos taurus
3-nitrophthalhydrazide IC50: 0.072 mM Bos taurus
3-nitrosalicylamide IC50: 1.6 mM Bos taurus
4,8-dihydroxy-2-quinolinecarboxylic acid IC50: 0.19 mM Bos taurus
4-amino-1,8-naphthalimide IC50: 0.00018 mM Bos taurus
4-Aminobenzamide IC50: 1.8 mM Bos taurus
4-aminophthalhydrazide IC50: 0.29 mM Bos taurus
4-bromobenzamide IC50: 2.2 mM Bos taurus
4-chlorobenzamide IC50: 0.3 mM Bos taurus
4-chromanone IC50: 0.72 mM Bos taurus
4-fluorobenzamide IC50: 0.2 mM Bos taurus
4-hydroxy-2-methylquinoline IC50: 0.074 mM Bos taurus
4-hydroxy-2-quinolinecarboxylic acid IC50: 0.67 mM Bos taurus
4-hydroxybenzamide IC50: 0.28 mM Bos taurus
4-Hydroxycoumarin IC50: 0.57 mM Bos taurus
4-hydroxypyridine IC50: 2.3 mM Bos taurus
4-hydroxyquinazoline IC50: 0.0095 mM Bos taurus
4-hydroxyquinoline IC50: 0.08 mM Bos taurus
4-methoxybenzamide IC50: 1.1 mM Bos taurus
4-methylbenzamide IC50: 1.8 mM Bos taurus
4-nitrophthalhydrazide IC50: 0.51 mM Bos taurus
4-[[[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl](pyridin-2-ylsulfonyl)amino]methyl]-N,N-dimethylpiperidine-1-carboxamide activates in presence of Mg2+, inhibits in absence of Mg2+ Bos taurus
5-acetamidosalicylamide IC50: 0.045 mM Bos taurus
5-aminosalicylamide IC50: 0.1 mM Bos taurus
5-Bromouracil IC50: 0.16 mM Bos taurus
5-Bromouridine IC50: 0.21 mM Bos taurus
5-chlorosalicylamide IC50: 0.19 mM Bos taurus
5-Chlorouracil IC50: 0.27 mM Bos taurus
5-hydroxy-1,4-naphthoquinone IC50: 0.25 mM Bos taurus
5-Hydroxy-2-methyl-1,4-naphthoquinone IC50: 0.7 mM Bos taurus
5-Iodouracil IC50: 0.071 mM Bos taurus
5-iodouridine IC50: 0.043 mM Bos taurus
5-Methylnicotinamide IC50: 0.35 mM Bos taurus
5-methyluracil IC50: 0.29 mM Bos taurus
5-Nitrouracil IC50: 0.43 mM Bos taurus
6(5H)-phenanthridinone IC50: 0.0003 mM Bos taurus
6-aminocoumarin IC50: 0.85 mM Bos taurus
6-aminonicotinamide IC50: 1.1 mM Bos taurus
8-acetamidocarsalam IC50: 1.4 mM Bos taurus
acetophenone IC50: 2.3 mM Bos taurus
all-trans-retinal IC50: 0.45 mM Bos taurus
alpha-picolinamide IC50: 0.25 mM Bos taurus
arachidonic acid
-
 Bos taurus
Benzamide IC50: 0.22 mM Bos taurus
benzoyleneurea IC50: 0.0081 mM Bos taurus
carbonylsalicylamide IC50: 0.46 mM Bos taurus
carsalam 5 mM, 88% inhibition in presence of Mg2+, 68% inhibition in absence of Mg2+ Bos taurus
Chlorthenoxazin IC50: 0.0085 mM Bos taurus
chromone-2-carboxylic acid IC50: 0.56 mM Bos taurus
cyclohexanecarboxamide IC50: 0.62 mM Bos taurus
EDTA 5 mM, 41% inhibition in presence of Mg2+, 2% inhibition in absence of Mg2+ Bos taurus
flavone IC50: 0.022 mM Bos taurus
gamma-linolenic acid IC50: 0.12 mM Bos taurus
Isonicotinamide IC50: 0.99 mM Bos taurus
Isoquinoline 5 mM, 47% inhibition in presence of Mg2+, 34% inhibition in absence of Mg2+ Bos taurus
linoleic acid IC50: 0.048 mM Bos taurus
linolenic acid IC50: 0.11 mM Bos taurus
m-acetamidoacetophenone IC50: 0.93 mM Bos taurus
m-aminoacetophenone IC50: 1.9 mM Bos taurus
m-hydroxyacetophenone IC50: 0.6 mM Bos taurus
m-phthalamide IC50: 0.05 mM Bos taurus
menadione sodium bisulfite IC50: 0.72 mM Bos taurus
N-(2-chloroethyl)1,8-naphthalamide IC50: above 1.8 mM Bos taurus
N-hydroxynaphthalimide sodium salt IC50: 0.45 mM Bos taurus
nicotinamide IC50: 0.21 mM Bos taurus
norharman IC50: 4.7 mM Bos taurus
novobiocin IC50: 2.2 mM, 5 mM, 90% inhibition in presence of Mg2+, 59% inhibition in absence of Mg2+ Bos taurus
oleic acid IC50: 0.082 mM Bos taurus
palmitoleic acid IC50: 0.095 mM Bos taurus
phthalamide IC50: 1.0 mM Bos taurus
Phthalazine 5 mM, 91% inhibition in presence of Mg2+, 79% inhibition in absence of Mg2+ Bos taurus
Quinazoline 5 mM, 63% inhibition in presence of Mg2+, 50% inhibition in absence of Mg2+ Bos taurus
reserpine IC50: 0.79 mM Bos taurus
thiobenzamide IC50: 0.62 mM Bos taurus
Thionicotinamide IC50: 1.8 mM Bos taurus
thymidine IC50: 0.18 mM Bos taurus
trans-decahydro-1-naphthalenone IC50: 4.3 mM Bos taurus
vitamin K1 IC50: 0.0019 mM Bos taurus
vitamin K3 IC50: 0.42 mM Bos taurus
xanthurenic acid 5 mM, 88% inhibition in presence of Mg2+, 65% inhibition in absence of Mg2+ Bos taurus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ activates Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
thymus
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NAD+ + (ADP-D-ribosyl)n-acceptor
-
 Bos taurus nicotinamide + (ADP-D-ribosyl)n+1-acceptor
-
 ?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00018
-
 IC50: 0.00018 mM Bos taurus 4-amino-1,8-naphthalimide
0.0003
-
 IC50: 0.0003 mM Bos taurus 2H-benz[c]isoquinolin-1-one
0.0003
-
 IC50: 0.0003 mM Bos taurus 6(5H)-phenanthridinone
0.00035
-
 IC50: 0.00035 mM Bos taurus 2-nitro-6(5H)-phenanthridione
0.00039
-
 IC50: 0.00039 mM Bos taurus 1,5-dihydroxyisoquinoline
0.0014
-
 IC50: 0.0014 mM Bos taurus 1,8-naphthalimide
0.0014
-
 IC50: 0.0014 mM Bos taurus 2H-benz[de]isoquinoline-1,3-dione
0.0019
-
 IC50: 0.0019 mM Bos taurus vitamin K1
0.007
-
 IC50: 0.007 mM Bos taurus 1-hydroxyisoquinoline
0.0081
-
 IC50: 0.0081 mM Bos taurus 2,4(1H,3H)-quinazolinedione
0.0081
-
 IC50: 0.0081 mM Bos taurus benzoyleneurea
0.0085
-
 IC50: 0.0085 mM Bos taurus Chlorthenoxazin
0.0091
-
 IC50: 0.0091 mM Bos taurus 3-Hydroxybenzamide
0.0095
-
 IC50: 0.0095 mM Bos taurus 4-hydroxyquinazoline
0.012
-
 IC50: 0.012 mM Bos taurus 3-Acetamidobenzamide
0.012
-
 IC50: 0.012 mM Bos taurus 1(2H)-phthalazinone
0.017
-
 IC50: 0.017 mM Bos taurus 3-Methoxybenzamide
0.022
-
 IC50: 0.022 mM Bos taurus flavone
0.022
-
 IC50: 0.022 mM Bos taurus 2-phenylchromone
0.023
-
 IC50: 0.023 mM Bos taurus 3-Aminophthalhydrazide
0.03
-
 IC50: 0.03 mM Bos taurus 2,3-dihydro-1,4-phthalazinedione
0.043
-
 IC50: 0.043 mM Bos taurus 5-iodouridine
0.044
-
 IC50: 0.044 mM Bos taurus 2-mercapto-4(3H)-quinazolinone
0.045
-
 IC50: 0.045 mM Bos taurus 2-methyl-1,4-benzopyrone
0.045
-
 IC50: 0.045 mM Bos taurus 2-methylchromone
0.045
-
 IC50: 0.045 mM Bos taurus 5-acetamidosalicylamide
0.048
-
 IC50: 0.048 mM Bos taurus linoleic acid
0.05
-
 IC50: 0.05 mM Bos taurus m-phthalamide
0.055
-
 IC50: 0.055 mM Bos taurus 3-bromobenzamide
0.056
-
 IC50: 0.056 mM Bos taurus 2-methyl-4(3H)-quinazolinone
0.071
-
 IC50: 0.071 mM Bos taurus 5-Iodouracil
0.072
-
 IC50: 0.072 mM Bos taurus 3-nitrophthalhydrazide
0.074
-
 IC50: 0.074 mM Bos taurus 4-hydroxy-2-methylquinoline
0.08
-
 IC50: 0.08 mM Bos taurus 4-hydroxyquinoline
0.082
-
 IC50: 0.082 mM Bos taurus oleic acid
0.095
-
 IC50: 0.095 mM Bos taurus palmitoleic acid
0.1
-
 IC50: 0.1 mM Bos taurus 5-aminosalicylamide
0.11
-
 IC50: 0.11 mM Bos taurus linolenic acid
0.12
-
 IC50: 0.12 mM Bos taurus gamma-linolenic acid
0.12
-
 IC50: 0.12 mM Bos taurus 2-fluorobenzamide
0.12
-
 IC50: 0.12 mM Bos taurus 3-(N,N-dimethylamino)benzamide
0.15
-
 IC50: 0.15 mM Bos taurus 2,3-benzodiazine
0.16
-
 IC50: 0.16 mM Bos taurus 5-Bromouracil
0.16
-
 IC50: 0.16 mM Bos taurus 3-nitrobenzamide
0.18
-
 IC50: 0.18 mM Bos taurus thymidine
0.18
-
 IC50: 0.18 mM Bos taurus 2,6-difluorobenzamide
0.19
-
 IC50: 0.19 mM Bos taurus 3-Methylbenzamide
0.19
-
 IC50: 0.19 mM Bos taurus 4,8-dihydroxy-2-quinolinecarboxylic acid
0.19
-
 IC50: 0.19 mM Bos taurus 5-chlorosalicylamide
0.2
-
 IC50: 0.2 mM Bos taurus 2-Methoxybenzamide
0.2
-
 IC50: 0.2 mM Bos taurus 3-Fluorobenzamide
0.2
-
 IC50: 0.2 mM Bos taurus 4-fluorobenzamide
0.21
-
 IC50: 0.21 mM Bos taurus nicotinamide
0.21
-
 IC50: 0.21 mM Bos taurus 5-Bromouridine
0.22
-
 IC50: 0.22 mM Bos taurus Benzamide
0.22
-
 IC50: 0.22 mM Bos taurus 3-Chlorobenzamide
0.25
-
 IC50: 0.25 mM Bos taurus 5-hydroxy-1,4-naphthoquinone
0.25
-
 IC50: 0.25 mM Bos taurus 1,4-naphthalenedione
0.25
-
 IC50: 0.25 mM Bos taurus alpha-picolinamide
0.26
-
 IC50: 0.26 mM Bos taurus 2,3-dichloro-1,4-naphthoquinone
0.27
-
 IC50: 0.27 mM Bos taurus 5-Chlorouracil
0.28
-
 IC50: 0.28 mM Bos taurus 4-hydroxybenzamide
0.29
-
 IC50: 0.29 mM Bos taurus 5-methyluracil
0.29
-
 IC50: 0.29 mM Bos taurus 4-aminophthalhydrazide
0.3
-
 IC50: 0.3 mM Bos taurus 4-chlorobenzamide
0.31
-
 IC50: 0.31 mM Bos taurus 3,4-dihydro-1(2H)-naphthalenone
0.33
-
 IC50: 0.33 mM Bos taurus 2-Hydroxy-1,4-naphthoquinone
0.33
-
 IC50: 0.33 mM Bos taurus 3-aminobenzamide
0.35
-
 IC50: 0.35 mM Bos taurus 5-Methylnicotinamide
0.4
-
 IC50: 0.4 mM Bos taurus 1,4-benzoquinone
0.42
-
 IC50: 0.42 mM Bos taurus 2-methyl-1,4-naphthoquinone
0.42
-
 IC50: 0.42 mM Bos taurus vitamin K3
0.43
-
 IC50: 0.43 mM Bos taurus 5-Nitrouracil
0.45
-
 IC50: 0.45 mM Bos taurus all-trans-retinal
0.45
-
 IC50: 0.45 mM Bos taurus N-hydroxynaphthalimide sodium salt
0.46
-
 IC50: 0.46 mM Bos taurus carbonylsalicylamide
0.51
-
 IC50: 0.51 mM Bos taurus 4-nitrophthalhydrazide
0.52
-
 IC50: 0.52 mM Bos taurus 2-methyl-3-phytyl-1,4-naphthoquinone
0.56
-
 IC50: 0.56 mM Bos taurus 3,5-dibromosalicylamide
0.56
-
 IC50: 0.56 mM Bos taurus chromone-2-carboxylic acid
0.57
-
 IC50: 0.57 mM Bos taurus 4-Hydroxycoumarin
0.6
-
 IC50: 0.6 mM Bos taurus m-hydroxyacetophenone
0.62
-
 IC50: 0.62 mM Bos taurus thiobenzamide
0.62
-
 IC50: 0.62 mM Bos taurus cyclohexanecarboxamide
0.65
-
 IC50: 0.65 mM Bos taurus 2-Aminobenzamide
0.67
-
 IC50: 0.67 mM Bos taurus 4-hydroxy-2-quinolinecarboxylic acid
0.7
-
 IC50: 0.7 mM Bos taurus 5-Hydroxy-2-methyl-1,4-naphthoquinone
0.72
-
 IC50: 0.72 mM Bos taurus menadione sodium bisulfite
0.72
-
 IC50: 0.72 mM Bos taurus 4-chromanone
0.79
-
 IC50: 0.79 mM Bos taurus reserpine
0.81
-
 IC50: 0.81 mM Bos taurus 1-Indanone
0.82
-
 IC50: 0.82 mM Bos taurus 2-hydroxybenzamide
0.82
-
 IC50: 0.82 mM Bos taurus 2-amino-3-chloro-1,4-naphthoquinone
0.85
-
 IC50: 0.85 mM Bos taurus 6-aminocoumarin
0.93
-
 IC50: 0.93 mM Bos taurus m-acetamidoacetophenone
0.99
-
 IC50: 0.99 mM Bos taurus Isonicotinamide
1
-
 IC50: 1.0 mM Bos taurus 2-chlorobenzamide
1
-
 IC50: 1.0 mM Bos taurus 2-acetamidobenzamide
1
-
 IC50: 1.0 mM Bos taurus phthalamide
1.1
-
 IC50: 1.1 mM Bos taurus 6-aminonicotinamide
1.1
-
 IC50: 1.1 mM Bos taurus 4-methoxybenzamide
1.2
-
 IC50: 1.2 mM Bos taurus 3,5-dimethoxybenzamide
1.3
-
 IC50: 1.3 mM Bos taurus 1,3-dihydroxynaphthalene
1.3
-
 IC50: 1.3 mM Bos taurus 1-hydroxy-2-methyl-4-aminonaphthalene
1.4
-
 IC50: 1.4 mM Bos taurus 8-acetamidocarsalam
1.5
-
 IC50: 1.5 mM Bos taurus 2-methylbenzamide
1.6
-
 IC50: 1.6 mM Bos taurus 3-nitrosalicylamide
1.8
-
 IC50: 1.8 mM Bos taurus Thionicotinamide
1.8
-
 IC50: 1.8 mM Bos taurus 4-Aminobenzamide
1.8
-
 IC50: 1.8 mM Bos taurus 4-methylbenzamide
1.8
-
 IC50: above 1.8 mM Bos taurus N-(2-chloroethyl)1,8-naphthalamide
1.9
-
 IC50: 1.9 mM Bos taurus m-aminoacetophenone
2
-
 IC50: 2.0 mM Bos taurus 1,3-benzodiazine
2
-
 IC50: 2.0 mM Bos taurus 3-acetamidosalicylamide
2.2
-
 IC50: 2.2 mM Bos taurus 4-bromobenzamide
2.2
-
 IC50: 2.2 mM Bos taurus 2-trichloromethyl-4(3H)-quinazolinone
2.2
-
 IC50: 2.2 mM, 5 mM, 90% inhibition in presence of Mg2+, 59% inhibition in absence of Mg2+ Bos taurus novobiocin
2.3
-
 IC50: 2.3 mM Bos taurus acetophenone
2.3
-
 IC50: 2.3 mM Bos taurus 4-hydroxypyridine
2.5
-
 IC50: 2.5 mM Bos taurus 3,5-dinitrobenzamide
2.8
-
 IC50: 2.8 mM Bos taurus 1,2-benzopyrone
2.9
-
 IC50: 2.9 mM Bos taurus 2-bromobenzamide
3.8
-
 IC50: 3.8 mM Bos taurus 1-methylnicotinamide chloride
4.3
-
 IC50: 4.3 mM Bos taurus trans-decahydro-1-naphthalenone
4.7
-
 IC50: 4.7 mM Bos taurus norharman